小鼠对新环境和回避反应的记忆特征:开阔行为和避暗实验比较(英文)

目的:研究小鼠对新环境和回避反应记忆特点.方法:用开阔和避暗实验.结果:小鼠对开阔环境记忆仅保持48 h,对回避反应记忆持续96 h以上.在开阔和回避反应实验中,小鼠获得记忆所需的学习时间分别为0.5和2min.东莨菪碱,氯丙嗪,异丙嗪,印防己毒素,咖啡因和戊巴比妥能抑制小鼠回避反应.但小鼠对开阔环境的记忆仅被东茛菪碱和咖啡因阻断.结论:与回避反应相比,小鼠对新环境的记忆表现为易获得,易消退,不易被药物阻断.

Features of memory on novel situation and avoidance response: evidence from comparisons between open-field behavior and step-through task

AIM:To study the features of memory on novel situation and avoidance response in mice. METHODS: Open-field activity and step-through latency were used to determine the memory of mice on a new environment and avoidance, respectively. RESULTS:The open-field memory was only observed 24 and 48 h after acquisition session. The avoidance memory still existed 72 and 96 h after training session. On d 1 mice were allowed to remain on open-field and step-through for 0. 5, 1, 3, and 5 min. On d 2 the retention latencies in 0.5- and 1-min groups were shorter than those in 3- and 5-min groups,while the recall activities in open-field were indifferent between these groups. Scopolamine (1 mg.kg-1) and caffeine (200 mg.kg-1) injected ip 15 min before the first session inhibited the avoidance response and the adaptation to open-field environment in mice. Chlorpromazine, promet-hazine, picrotoxin and pentobarbital impaired the avoidance memory, but not impaired the open-field memory. CONCLUSION: These results supported the hypothesis that the adaptation of mice on open-field was a short or medium term memory.