Erectile dysfunction in the cardiac patient |
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Authors: | Robert A Kloner |
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Institution: | (1) Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, 90017 Los Angeles, CA, USA |
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Abstract: | Erectile dysfunction (ED) often is caused by endothelial dysfunction and may be a sign that a patient has vascular disease
elsewhere in the body. Risk factors for coronary artery disease such as lipid abnormalities, smoking, diabetes, and hypertension
also are risk factors for ED. Oral therapy for ED, such as sildenafil, inhibits phosphodiesterase-5 (PDE-5) and the breakdown
of cyclic guanosine monophosphate. PDE-5 inhibitors have been shown to be safe and effective for the therapy for ED, but remain
contraindicated in patients receiving organic nitrates. These agents are mild vasodilators and are being investigated for
their treatment potential for patients with pulmonary hypertension, heart failure, and endothelial dysfunction. |
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Keywords: | |
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