Effects of Prolylendopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Experimental Depressive Syndrome Development in Rats |
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Authors: | N N Khlebnikova N A Krupina N G Bogdanova N N Zolotov and G N Kryzhanovskii |
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Institution: | (1) Laboratory of General Pathology and Pathophysiology of Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |
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Abstract: | Model of experimental depressive syndrome in rats induced by repeated systemic injection of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
showed that chronic injection of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine 30 min before
pro-neurotoxin injection prevents the development of a number of depressive syndrome symptoms such as behavioral despair and
biorhythmic disorders in forced swimming test, precludes the increase in anxiety-phobic level, prevents reduction of relative
thymus mass. These results indicate that benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine possesses antidepressant, anxiolytic,
and/antistress properties.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 1, pp. 27–31, January, 2009 |
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Keywords: | experimental depressive syndrome 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine rats |
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