| p53和nm23蛋白表达与大肠癌浸润转移的关系 |
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| 引用本文： | 薛立娟,王维忠,张文岚,印璞.p53和nm23蛋白表达与大肠癌浸润转移的关系[J].中国免疫学杂志,2001,17(1):30-32. |
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| 作者姓名： | 薛立娟 王维忠 张文岚 印璞 |
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| 作者单位： | 1. 白求恩医科大学第三临床学院 中心研究室,
2. 吉林省临床检验中心, |
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| 摘 要： | 目的：探讨大肠癌组织中ｐ５３和ｎｍ２３蛋白表达与癌组织分化浸润转移的关系，以及它们之间的相关性。方法：应用免疫组织化学（ＳＡＢＣ）方法对４１例大肠癌组织中ｐ５３和ｎｍ２３蛋白表达情况进行检测。结果：大肠癌组织中ｐ５３和ｎｍ２３蛋白表达的阳性率分别为５８．５％和５３．７％，ｐ５３过表达、ｎｍ５３低表达与大肠癌浸润深度和淋巴转移具有相关性，ｐ５３过表达在低分化腺癌中明显高于高分化腺癌（Ｐ〈０．０１）；而ｎｍ２３高表达与大肠癌的分化程度无关（Ｐ〉０．０５）。ｎｍ２３低表达与ｐ５３高表达有相关性。结论：ｐ５３高表达、ｎｍ２３低表达在大肠癌的浸润转移中起重要作用，ｐ５３高表达与大肠癌组织分化程度有关，大肠癌组织浸润与淋巴转移可能与多基因异常改变有关。
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| 关 键 词： | 大肠肿瘤 基因表达 p53蛋白 nm23蛋白 肿瘤浸润 肿瘤转移 |
| 文章编号： | 1000-484X(2001)01-0030-03 |
The correlation of p53 and
nm23 expression with invasiveness and metastasis colorectal carcinoma |
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| XUE LiJuan,WANG Wei Zhong,ZHANG Wen Lan et al N Bethune University of Medical Sciences.The correlation of p53 and
nm23 expression with invasiveness and metastasis colorectal carcinoma[J].Chinese Journal of Immunology,2001,17(1):30-32. |
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| Authors: | XUE LiJuan WANG Wei Zhong ZHANG Wen Lan N Bethune University of Medical Sciences |
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| Institution: | XUE LiJuan,WANG Wei Zhong,ZHANG Wen Lan et al N Bethune University of Medical Sciences,Department of Central Research,Changchun 130031 |
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| Abstract: | Objective:To study the relationship between expression of p53,nm23 and invasion and metastasis in human colorectal carcinoma,and the correlation between expression of p53 and nm23.Methods:Expression of p53 and nm23 were studied with SABC immunohistochemical technique Results:The positive rate of p53 and nm23 in 41 samples of human colorectal carcinoma was 58 5% and 53 7% respectively p53 over expression and nm23 low expression was significantly correlated with the depth of invasion and lymphatic metastasis The expression of p53 in pooly differentiated carcinoma was obviously higher than that in well differentiated carcinoma(P<0 01) While the expression of nm23 showed no relation to the differentiation degree of carcinoma (P>0 05) p53 over expression was correlated with nm23 low expression Conclusion:Over expression of p53 and low expression of nm23 might play an important role in invasion and metastasis of human colorectal carcinoma p53 over expression was related to the differentiation of colorectal carcinoma tissue |
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| Keywords: | Colorectal carcinoma Gene expression Immunohistochemistry p53 protein nm23 protein |
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