Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs |
| |
Authors: | Li Li-Jie Yang Yun-Gao Zhang Zhi-Ling Nie Sui-Feng Li Ze Li Feng Hua He-Yu Hu Yan-Jun Zhang Hong-Shuan Guo Ya-Bing |
| |
Institution: | 1. No. 425 Central Hospital of PLA, Sanya 572008, Hainan Province, China 2. Department of Traditional Chinese Medicine, Southern Medical University,Guangzhou 510515, Guangdong Province, China 3. Department of Orthopaedics and Traumatology,Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China 4. Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515,Guangdong Province, China |
| |
Abstract: | AIM: To investigate the protective effect of medical ozone (O(3)) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl(4))-induced hepatic injury in dogs. METHODS: Thirty healthy dogs were divided randomly into five groups (n = 6 in each group), namely control, oleanolic acid tablet (OAT), O(3), YC and O(3) + YC, given either no particular pre-treatment, oral OAT, medical ozone rectal insulfflation every other day, oral YC, or oral YC plus medical ozone rectal insulfflation every other day, respectively, for 30 consecutive days. After pre-treatment, acute hepatic injury was induced in all dogs with a single-dose intraperitoneal injection of CCl(4). General condition and survival time were recorded. The biochemical and hematological indexes of alanine aminotransferase (ALT), aspartate aminotransferase/alanine aminotransferase (AST/ALT), serum total bilirubin (TBIL), prothrombin time (PT), blood ammonia (AMMO), and blood urea nitrogen (BUN) were measured after CCl(4) injection. Hepatic pathological changes were also observed. RESULTS: Compared to the other four groups, the changes of group O(3) + YC dogs' general conditions (motoricity, mental state, eating, urination and defecation) could be better controlled. In group O(3) + YC the survival rates were higher (P < 0.05 vs group control). AST/ALT values were kept within a normal level in group O(3) + YC. Hepatic histopathology showed that hepatic injury in group O(3) + YC was less serious than those in the other four groups. CONCLUSION: Medical ozone combined with TCM YC could exert a protective effect on acute liver injury induced by CCl(4). |
| |
Keywords: | Carbon tetrachloride Ozone Traditional Chinese Medicine |
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录! |
|