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Randomized Comparison of Prostatic Artery Embolization versus Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia
Institution:1. Department of Interventional Radiology, Complejo Hospitalario de Navarra, Pamplona, Spain;2. Department of Pharmacy, Complejo Hospitalario de Navarra, Pamplona, Spain;3. Department of Urology, Complejo Hospitalario de Navarra, Pamplona, Spain;4. Navarrabiomed, Complejo Hospitalario de Navarra-Universidad Pública de Navarra, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Pamplona, Spain;5. Department of Interventional Radiology, Hospital St. Louis, Lisbon, Portugal;6. Department of Radiology, NOVA Medical School, Lisbon, Portugal;7. Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal;8. Division of Vascular and Interventional Radiology, Department of Radiology, University of North Carolina Medical Center, Chapel Hill, North Carolina;1. Yale University School of Medicine, 360 State Street, #3206, New Haven, CT 06511;2. University of Miami School of Medicine, Miami, Florida;3. Hartford Healthcare, Hartford, Connecticut;1. University of North Carolina at Chapel Hill School of Medicine, 101 Manning Drive, Chapel Hill, NC 27514;2. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;3. Department of Interventional Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;4. Vascular Institute of Virginia, Woodbridge, Virginia;1. Department of Radiology, University of North Carolina, 101 Manning Dr., Chapel Hill, NC 27514;2. Department of Urology, University of North Carolina, 101 Manning Dr., Chapel Hill, NC 27514
Abstract:PurposeTo compare clinical and functional outcomes of prostatic artery embolization (PAE) with those of transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).Materials and MethodsNoninferiority randomized trial was conducted involving men over 60 years of age with LUTS secondary to BPH. From November 2014 to January 2017, 45 patients were randomized to PAE (n = 23) or to TURP (n = 22). PAE was performed with 300- to 500-μm microspheres with the patient under local anesthesia, whereas bipolar TURP was performed with the patients under spinal or general anesthesia. Primary outcomes were changes in peak urinary flow (Qmax) and international prostate symptoms score (IPSS) from baseline to 12 months. Quality of life (QoL), and prostate volume (PV) changes from baseline to 12 month were secondary outcomes. Adverse events were compared using the Clavien classification.ResultsMean Qmax increased from 6.1 mL/s in the PAE group and from 9.6 mL/s in the TURP patients (P = .862 for noninferiority), and mean IPSS reduction was 21.0 points for PAE and 18.2 points for TURP subjects (P = .080) at 12 months. A greater QoL improvement was reported in the PAE group (3.78 points for PAE and 3.09 points for TURP; P = .002). Mean PV reduction was 20.5 cm³ (34.2%) for PAE subjects and 44.7 cm³ (71.2%) for TURP subjects (P < .001). There were fewer adverse events reported in the PAE group than in the TURP group (n = 15 vs n = 47; P < .001).ConclusionsReduction of LUTS in the PAE group was similar to that in the TURP group at 12 months, with fewer complications secondary to PAE. Long-term follow-up is needed to compare the durability of the symptomatic improvement from each procedure.
Keywords:BPH"}  {"#name":"keyword"  "$":{"id":"kwrd0015"}  "$$":[{"#name":"text"  "_":"benign prostatic hyperplasia  LUTS"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"lower urinary tract symptoms  PAE"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"prostatic artery embolization  TURP"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"transurethral resection of the prostate
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