Predictors of Occlusion of Hepatic Blood Vessels after Irreversible Electroporation of Liver Tumors |
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| Institution: | 1. Department of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, Aachen, Germany;2. Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany;3. Department of Radiology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan;1. Department of Interventional Radiology, Pisa University Hospital, via Paradisa 2, 56100 Pisa, Italy;2. Department of Nuclear Medicine, Pisa University Hospital, via Paradisa 2, 56100 Pisa, Italy;3. Department of Health Physics, Pisa University Hospital, via Paradisa 2, 56100 Pisa, Italy;1. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China;2. Shanghai Institution of Medical Imaging, Shanghai, China;3. Department of General Surgery, Shanghai Pudong New Area People’s Hospital, Shanghai, China;1. Department of Radiology, Ludwig-Maximilians University, Munich, Germany;2. Pathological Institute, Ludwig-Maximilians University, Munich, Germany;3. Evidensia Veterinary Clinic for Small Animals GmbH Norderstedt, Norderstedt, Germany;4. Research and Development Laboratory, microParticles GmbH, Berlin, Germany;5. Department of Radiology, Charité, Humboldt University Medical School, Berlin, Germany;1. Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing, China;2. School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China;3. Division of Interventional Radiology, Stanford University School of Medicine, Palo Alto, California;4. Department of Interventional Radiology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China;1. Section of Interventional Radiology, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;2. Division of Vascular Surgery, Department of Surgery, Penn Presbyterian Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania |
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| Abstract: | PurposeTo examine predictors of midterm occlusion in portal and hepatic veins within or adjacent to the ablation zone after irreversible electroporation (IRE) of liver tumors.Materials and MethodsThis retrospective cohort analysis included 39 patients who underwent CT-guided IRE of liver tumors. Vessels within or adjacent to the ablation zone were identified on CT images acquired immediately after the procedure, and the positional relationships with the ablation zone (within/adjacent), locations (proximal/distal), and diameters (< 4 mm or ≥ 4 mm) were evaluated. Using contrast-enhanced follow-up scans, each vessel was classified as patent, stenosed, or occluded. Associations between vessel occlusion and each variable were investigated.ResultsOverall, 33 portal veins and 64 hepatic veins were analyzed. Follow-up scans showed occlusion in 12/33 (36.7%) portal veins and 17/64 (26.6%) hepatic veins. Vessels within the ablation zone were occluded significantly more frequently than vessels adjacent to the ablation zone (portal: 55.6% 10/18] vs 13.3% 2/15], P = .04; hepatic: 45.4% 15/33] vs 6.4% 2/31], P = .011). Vessels with a diameter < 4 mm were also occluded significantly more frequently than vessels with a diameter ≥ 4 mm (portal: 72.7% 8/11] vs 18.1% 4/22], P = .011; hepatic: 54.8% 17/31] vs 0% 0/33], P < .001). The respective positive and negative predictive values for occlusion of vessels categorized as both within and < 4 mm were 88% (7/8) and 82% (20/25) for portal veins and 79% (15/19) and 96% (43/45) for hepatic veins.ConclusionsMidterm vessel occlusion after liver IRE could be predicted with relatively high accuracy by assessing ablation location and vessel diameter. |
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| Keywords: | IRE"} {"#name":"keyword" "$":{"id":"kwrd0015"} "$$":[{"#name":"text" "_":"irreversible electroporation MW"} {"#name":"keyword" "$":{"id":"kwrd0025"} "$$":[{"#name":"text" "_":"microwave |
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