Double-Needle Lavage for Effective Treatment of Difficult-Aspiration Thyroid Cystic Nodules: A Single-Center Controlled Trial |
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| Affiliation: | 1. Department of Tumor Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160# Pujian Road, Shanghai, 200127, China;2. Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160# Pujian Road, Shanghai, 200127, China;1. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 646 BRB II/III, 421 Curie Blvd., Philadelphia, PA 19104;2. Medivis, Brooklyn, New York;1. Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China;2. Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China;1. Department of Radiology, Division of Interventional Radiology, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ, 85724;2. Department of Radiology, Section of Interventional Radiology, University of Chicago Medicine, Chicago, Illinois;1. Section of Interventional Radiology, Department of Radiology, Northwestern University, 676 North St. Clair, Suite 800, Chicago, IL 60611;2. Division of Hematology and Oncology, Department of Medicine, Northwestern University, 676 North St. Clair, Suite 800, Chicago, IL 60611 |
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| Abstract: | PurposeTo explore the safety and efficacy of double-needle lavage (DNL) in the treatment of difficult aspiration thyroid cystic nodules.Materials and MethodsThis single-center, prospective, randomized controlled trial was conducted using 100 thyroid cysts from 100 patients who were treated in our hospital from January 2018 to August 2019. These patients were placed into 2 groups; group A including 40 patients treated with single-needle aspiration (SNA), and group B including 60 patients treated with DNL. The safety and efficacy of these 2 aspiration methods were compared.ResultsTen patients in group A that did not benefit from SNA were transferred to group B. No complication occurred in either group. Notably, DNL showed significantly higher efficacy than SNA. This was evidenced by the higher extraction rate of materials in the capsule (A vs B, 91 ± 6.51% vs 98.45 ± 1.74%, P < .001) and overall nodule volume reduction rate in group B (A vs B, 87.54 ± 7.84% vs 95.62 ± 3.66%, P < .001). In group B, patients who received DNL treatment with 2 needles pointed at the upper and lower extremes of the cystic nodules (B2) exhibited significantly better aspiration effects compared to patients in which the 2 needles were pointed at the same ultrasound plane (B1) (P < .05), especially for patients with maximum diameter of nodules ≥3 cm (P < .01).ConclusionsDNL treatment could efficiently and safely replace cystic material from thyroid gland. Moreover, our results indicate that DNL treatment in which 2 needles are pointed at the 2 extremes of cystic nodules yields higher efficacy in patients with maximum diameter of nodules ≥3 cm. |
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