Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients |
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| Institution: | 1. Department of Interventional Radiology, Northside Hospital, Atlanta, Georgia;2. Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina;3. Department of Radiology, Mayo Clinic, Rochester, Minnesota;4. Department of Neurosurgery, Moffitt Cancer Center, Tampa, Florida;5. Department of Interventional Radiology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;6. Department of Neurointerventional Radiology, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts;7. Department of Neurointerventional Radiology, St. Jude Medical Center, Fullerton, California;8. Department of Interventional Radiology, Renown Regional Medical Center, Reno, Nevada;9. Department of Interventional Radiology, Emory University School of Medicine, Atlanta, Georgia;10. Department of Radiology, Banner–University Medical Center, Phoenix, Arizona;11. Department of Interventional Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;12. Department of Interventional Radiology, Hôpitaux Universitaires de Strasbourg–Nouvel Hôpital Civil, Strasbourg, France;13. Department of Orthopedic, Trauma and Plastic Surgery, Universitätsklinikum Leipzig AöR, Leipzig, Germany;14. Department of Interventional Radiology, Prostate Centers USA, LLC, Vascular Interventional Partners NOVA, 2755 Hartland Road, Falls Church, VA 22043 |
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| Abstract: | PurposeTo evaluate the effectiveness of radiofrequency (RF) ablation as measured by change in worst pain score from baseline to 3 mo after RF ablation for the palliative treatment of painful bone metastases.Materials and MethodsOne hundred patients (mean age, 64.6 y) underwent RF ablation for metastatic bone disease and were followed up to 6 mo. Subjects’ pain and quality of life were measured before RF ablation and postoperatively by using the Brief Pain Index and European Quality of Life questionnaires. Opioid agent use and device-, procedure-, and/or therapy-related adverse events (AEs) were collected.ResultsEighty-seven patients were treated for tumors involving the thoracolumbar spine and 13 for tumors located in the pelvis and/or sacrum. All ablations were technically successful, and 97% were followed by cementoplasty. Mean worst pain score decreased from 8.2 ± 1.7 at baseline to 3.5 ± 3.2 at 6 mo (n = 22; P < 0.0001 for all visits). Subjects experienced significant improvement for all visits in average pain (P < .0001), pain interference (P < .0001), and quality of life (P < .003). Four AEs were reported, of which 2 resulted in hospitalization for pneumonia and respiratory failure. All 30 deaths reported during the study were attributed to the underlying malignancy and not related to the study procedure.ConclusionsResults from this study show rapid (within 3 d) and statistically significant pain improvement with sustained long-term relief through 6 mo in patients treated with RF ablation for metastatic bone disease. |
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