Intermediate to Long-Term Clinical Outcomes of Percutaneous Cryoablation for Renal Masses |
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| Affiliation: | 2. Department of Intervention Medicine, the Second Hospital of Shandong University, 247 Beiyuan Road, Jinan 250033, Shandong, People’s Republic of China;1. Department of Intervention Medicine, the First Hospital of Nanping Affiliated to Fujian Medical University, Nanping, Fujian, China;3. Interventional Oncology Institute of Shandong University, Jinan, Shandong, People’s Republic of China;4. Department of Radiology, Ben Gurion University of the Negev, Beersheba, Israel;1. Department of Diagnostic Imaging, Rhode Island Hospital, Providence, Rhode Island;2. Warren Alpert Medical School of Brown University, Providence, Rhode Island;3. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China;4. Yale School of Medicine, New Haven, Connecticut;5. Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China;2. Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA;3. Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China;4. Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA;5. Department of Neurosurgery, Xiangya Hospital, Central South University, Hunan, China;6. Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China;7. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA;8. Department of Radiology, Brigham and Women''s Hospital, Boston, Massachusetts, USA;9. Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA;1. Department of Urology, University of Texas Health, San Antonio, Texas;2. Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900;3. Department of Radiology, Division of Interventional Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900;4. Plummer Library, Mayo Clinic, Rochester, Minnesota |
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| Abstract: | PurposeThe purpose of this study was to evaluate the effectiveness and adverse outcomes of percutaneous cryoablation (CA) for treatment of renal masses in a large cohort of patients.Materials and MethodsThis retrospective analysis included 299 CA procedures (297 masses in 277 patients) performed between July 2007 and May 2018 at a single institution. The mean patient age was 66.1 years (range, 30–93 years) with 65.8% being male. A total of 234 (78.8%) masses were biopsy-proven renal cell carcinoma (RCC). The mean maximal tumor diameter was 2.5 cm (range, 0.7–6.6 cm). Efficacy was assessed only for ablations of biopsy-proven RCC, whereas the evaluation of adverse events and renal function included all masses. Complications were graded according to the Society of International Radiology classification.ResultsMajor complications occurred in 3.0% of procedures (n = 9), none of which resulted in death or permanent disability. The mean imaging follow-up period was 27.4 months (range, 1–115) for the 199 RCC patients (204 ablated tumors) with follow-up imaging available. Complete response on initial follow-up imaging at mean 4.2 months (range, 0.3–75.6) was achieved in 195 of 204 tumors (95.6%) after a single session and in 200 of 204 tumors (98.0%) after 1 or 2 sessions. Of the RCC patients achieving complete response initially, local recurrence during the follow-up period occurred in 3 of 200 tumors (1.5%). Metastatic progression occurred in 10 of 193 (5.2%) RCC patients without prior metastatic disease during follow-up.ConclusionsCA for renal masses is safe and remains efficacious through intermediate- and long-term follow-up. |
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