云南兰坪县肾综合征出血热调查

目的 调查云南省兰坪县人、鼠间肾综合征出血热（HFRS）的感染情况，为HFRS预防控制提供指导。方法 鼠类肺脏组织中汉坦病毒抗原检测采用直接免疫荧光法，人和鼠血清中汉坦病毒抗体检测采用间接免疫荧光法。结果 兰坪县3个乡镇共捕获5属158只啮齿动物，其中居民区中褐家鼠的构成比为91．09％，为优势种；野外高山姬鼠的构成比为63.16％，为优势种。3个乡镇中仅见中排乡捕获的褐家鼠（Rattus norvegic泌）汉坦病毒抗原的感染率为7．69％（5／65），臭蛊向鼠青（Suncus murinus）为25．00％（1／4），其他捕获的动物中未查出汉坦病毒抗原；宿主动物血清中汉坦病毒IgG抗体阳性率为12．20％（5／41），其中褐家鼠的阳性率为12，50％（5／40）；人群中汉坦病毒IgG抗体阳性率为7．00％（3／43）。结论 从兰坪县人群血清中查到汉坦病毒抗体，在宿主动物肺脏组织检测出汉坦病毒抗原，血清中查出汉坦病毒抗体，首次证实云南省兰坪县存在肾综合征出血热自然疫源地，为肾综合征出血热在该地区的预防控制提供了科学依据。

Survey of hemorrhagic fever with renal syndrome in Lanping County of Yunnan Province

Objective T survey the infectious status of hemorrhagic fever with renal syndrome (HFRS) in Lanping County,Yunnan Province and offer guidance for prevention and control of the disease. Methods Pulmonary tissue taken from rodents and the hattanvirus was detected with direct immunofluorescence assay,while antibody to Hattavirus in human and rodent indirect immunofluorescent assay. Results There 158 rodents belonged to 3 genus in three townships of Lanping County were captured and Rattus norvegicus caught in residential areas accounted for 90.09%. Apodemus agrarius was predominant in the field accounted for 63.16%. The infectious rates of Hattanvirus in Rattus norvegicus and Suncus murinus were 7.69% and 25.00%,respectively. Hattanvirus was not detected from other animals. The IgG antibody positive rate to Hattanvirus in the serum of hosts of rodents and human population were 12.20% and 7.00%. Conclusion There antibody to Hattanvirus has been detected from human serum and Hattanvirus and antibody have been detected from the lung tissue of rodent host,firstly showing that there is natural infectious area of HFRS in Lanping County that has provided scientific evidence for prevention and control of the disase.