| 骨髓异常增生综合征酪氨酸激酶受体FLT3和c-KIT基因表达异常的研究 |
| |
| 引用本文： | 宋强,周丽云,李丽珍,赵川莉,王鲁群.骨髓异常增生综合征酪氨酸激酶受体FLT3和c-KIT基因表达异常的研究[J].临床血液学杂志,2011(1). |
| |
| 作者姓名： | 宋强 周丽云 李丽珍 赵川莉 王鲁群 |
| |
| 作者单位： | 山东大学齐鲁医院血液科; |
| |
| 摘 要： | 目的:本研究旨在检测骨髓异常增生综合征(MDS)患者骨髓中酪氨酸激酶受体FLT3、c-KIT基因表达水平及FLT3-LM,以讨论FLT3、c-KIT受体对于MDS患者的临床意义。方法:收集38例诊断明确的MDS患者及10例非恶性血液病患者的骨髓并提取单个核细胞,应用PCR检测FLT3基因表达水平及FLT3基因长度突变(FLT3-LM);应用逆转录聚合酶链反应(RT-PCR)检测c-KIT基因表达水平。结果:38例MDS患者骨髓单个核细胞有11例检测到FLT3基因表达,而对照组均未有FLT3基因表达,2者差异有统计学意义(P<0.05)。11例FLT3受体表达阳性患者中有2例存在FLT3-LM,阳性率为18.2%,10例对照均未发现FLT3-LM。38例MDS患者中有7例检测到c-KIT基因表达,而10例对照组均未有c-KIT基因表达,阳性率为18.4%,2者差异有统计学意义(P<0.05),且FLT3-LM、c-KIT基因表达多为高危患者。结论:以上研究显示MDS患者存在FLT3、c-KIT基因表达异常,且FLT3-LM、c-KIT(+)多发生在高危患者。提示酪氨酸激酶受体FLT3、c-KIT基因表达异常对于...
|
| 关 键 词： | 骨髓异常增生综合征 基因 FLT3 FLT3-LM c-KIT |
c-KIT and tyrosine kinase receptor FLT3 mutations in myelodysplastic syndrome |
| |
| SONG Qiang ZHOU Liyun LI Lizhen ZHAO Chuanli WANG Luqun.c-KIT and tyrosine kinase receptor FLT3 mutations in myelodysplastic syndrome[J].Journal of Clinical Hematology,2011(1). |
| |
| Authors: | SONG Qiang ZHOU Liyun LI Lizhen ZHAO Chuanli WANG Luqun |
| |
| Institution: | SONG Qiang ZHOU Liyun LI Lizhen ZHAO Chuanli WANG Luqun(Department of Hematology,Qilu Hospital,Shandong University,Jinan,250012,China) |
| |
| Abstract: | Objective:This study is to investigate tyrosine kinase receptor FLT3 and c-KIT receptor expression and FLT3 length mutation (FLT3-LM) in the patients with myelodysplastic syndrome (MDS) and their clinical implication.Method:Analysis of FLT3-LM was performed on bone marrow samples from 38 patients with MDS by PCR and c-KIT gene expression by RT-PCR.Result:Eleven FLT-3 gene expression (28.9%) were found in 38 patients with myelodysplastic syndrome,compared with no expression in 10 controls (P<0.05). We also f... |
| |
| Keywords: | myelodysplastic syndrome gene FLT3 FLT3-LM c-KIT |
| 本文献已被 CNKI 等数据库收录！ |
|
