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通痹颗粒合甲氨喋呤对类风湿性关节炎患者VEGF的影响
引用本文:贺选玲,王莘智,游柏稳,范伏元. 通痹颗粒合甲氨喋呤对类风湿性关节炎患者VEGF的影响[J]. 湖南中医药大学学报, 2009, 29(4): 53-55
作者姓名:贺选玲  王莘智  游柏稳  范伏元
作者单位:湖南中医药大学第一附属医院,湖南长沙,410007
基金项目:湖南省自然科学基金资助项目,湖南省卫生厅中医药科研基金资助项目,湖南省重点学科中医内科学资助项目 
摘    要:目的探讨通痹颗粒合甲氨喋呤对类风湿性关节炎血管内皮生长因子(VEGF)的影响。方法将61例类风湿性关节炎患者随机分为治疗组(31例)和对照组(30例),治疗组予通痹颗粒和甲氨嗓呤,对照组予甲氨喋呤。分别观察两组患者给药3个月前后VEGF变化情况。结果通痹颗粒联合甲氨喋呤能明显改善VEGF水平(P〈0.05)。疗效优于对照组,差异具有统计学意义(P〈0.05)。结论通痹颗粒联合甲氨喋呤能降低血清VEGF的水平,其改善速度优于单用甲氨喋呤。

关 键 词:通痹颗粒  甲氨喋呤  类风湿性关节炎  血管内皮生长因子

Effects of Tongbi granules and methotrexate (MTX) on VEGF of rheumatoid arthritis (RA) patients
HE Xuan-ling,WANG Xin-zhi,YOU Bai-wen,FAN Fu-yuan. Effects of Tongbi granules and methotrexate (MTX) on VEGF of rheumatoid arthritis (RA) patients[J]. Journal of Traditional Chinese Medicine University of Hunan, 2009, 29(4): 53-55
Authors:HE Xuan-ling  WANG Xin-zhi  YOU Bai-wen  FAN Fu-yuan
Affiliation:HE Xuan-ling, WANG Xin-zhi, YOU Bai-wen, FAN. Fu-yuan (TCM University of Hunan, Changsha, Hunan 410007, China)
Abstract:Objective To discuss the curative effect mechanisms of Tongbi granules(TBG) and MTX in treating RA on effects of TBG and methotrexate (MTX) on VEGF of patients with rheumatoid arthritis (RA). Methods 61patients with RA were randomly derided into the testing group with TBG and MTX(31 cases) and the control group with MTX (30 cases). Results TBG and MTX remarkably reduced the index levels of blood VEGF. Conclusion TBG combined MTX is more effective than MTX alone to reduce VEGF.
Keywords:Tongbi granules  methotrexate  rheumatoid arthritis  vascular endothelial growth factor
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