| 山东省亚急型克山病患儿与柯萨奇B组病毒的关系 |
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| 引用本文： | 张凤民,张邻杰.山东省亚急型克山病患儿与柯萨奇B组病毒的关系[J].中国地方病防治杂志,1998,13(2):73-74. |
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| 作者姓名： | 张凤民 张邻杰 |
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| 作者单位： | 哈尔滨医科大学微生物教研室
(张凤民，牛美娟，郭彩玲)，哈尔滨医科大学克山病研究所
(张邻杰，周令望，刘艺)，山东省地方病防治研究所
(杨晓霞，房维堂)，哈尔滨医科大学克山病研究所(钟学宽) |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 为探讨山东省亚急型克山病患儿与柯萨奇Ｂ组病毒的关系，用缺口平移法制备生物素标记的ＣＯＸＢ３病毒的ｃＤＮＡ探针，与亚包型克山病病例尸检心肌组织９例及１５例脑外务，ＣＯ中毒等意外死亡的正常民人心肌组织和１０例非病区７～８个月胎儿心组织切片进行原位杂交，结果９例山东亚急型克山病的５例检测到ＣＯＸＢ组病毒的ＲＮＡ，阳性率为５５．５％（５／９），而对照组均为阴性，结果提示ＣＯＸＢ组病毒感染是山东省亚急性型克
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| 关 键 词： | 柯萨奇B组病毒 亚急型 克山病 原位杂交 儿童 |
RELATIONSHIP BETWEEN SUBACUTE KESHAN DISEASES IN SHANGDONG POVINCE AND COXSACKIE VIRUS B |
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| Zhang Fengmin
Research Laboratory of Microbiology,Ha''''erbin Medical University.RELATIONSHIP BETWEEN SUBACUTE KESHAN DISEASES IN SHANGDONG POVINCE AND COXSACKIE VIRUS B[J].Chinese Journal of Control of Endemic Disenaces,1998,13(2):73-74. |
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| Authors: | Zhang Fengmin
Research Laboratory of Microbiology Ha'erbin Medical University |
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| Abstract: | In order to research the relationship between subacute Keshan disease and Coxsackie virus in Shandong province ,we labelled cox B3 probe with Biotin by nick translation and detected myocardial specimens from 9 patients with subacute Keshan disease, ISpatients with cerebral trauma, 10 patients with carbon monoxide poisoning and 10 fetus aged 7 ~ 8months from non - endemic areas by in situ hybridization. The results showed that of 9 patients with subacute Keshan diseases ,5(56% ) showed positive findings,but the control samples were negative. These results suggested that Cox B infection may be one of the causes of subacute Keshan disease in Shandong provice. |
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| Keywords: | Coxsakie virus B Subacute Keshan diseases In situ hybridization |
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