Survivin和c-myc在分化型甲状腺癌中的表达及临床意义

目的　探讨甲状腺正常组织和分化型甲状腺癌 (DTC)中Survivin和c myc的表达及临床意义。方法　应用免疫组织化学SP法检测 10例腺瘤旁正常甲状腺组织和 5 7例DTC标本中Survivin和c myc的表达。 结果　Survivin和c myc在甲状腺正常组织中均呈阴性。在 5 7例DTC中Survivin和c myc的阳性表达率分别为 5 9.6%和 5 2 .6%。DTC中Survivin表达与肿瘤高分期和淋巴结转移密切相关 (P均 <0 .0 5 ) ;c myc表达与淋巴结转移有关 (P <0 .0 5 )。DTC中Survivin和c myc表达呈明显正相关 (P <0 .0 1)。 结论　Survivin和c myc在甲状腺癌发生发展中起到重要作用。Survivin有望成为甲状腺癌诊断和治疗的新靶点

Expression of survivin and c-myc in differentiated thyroid carcinoma and clinical significance

Objective To investigate the expression of survivin and c myc in thyroid normal tissue and differentiated thyroid carcinoma (DTC),and their clinical significance.Methods The expression of survivin and c myc in normal thyroid tissue around thyroid adenoma (10 cases) and DTC (57 cases) were detected by SP immunohistochemical technique.Results Survivin and c myc were negative in all of normal thyroid tissue,while the positive expression rate of survivin and c myc in DTC were 59.6 % and 52.6 % respectively.The expression of survivin was closely related to high TNM classification and lymph node metastasis (all P < 0.05), and the expression of c myc was related to lymph node metastasis ( P < 0.05). The expression of survivin was significantly correlated with the expression of c myc in DTC ( P <0.01).Conclusion Survivin and c myc play a pivotal role in the carcinogenesis and progression of thyroid carcinoma.Survivin could be a new diagnostic/therapeutic target in thyroid carcinoma.