Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells |
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Authors: | Francisco Roser Pérez-Perarnau Alba Cortés Constanza Gil Joan Tauler Albert Ambrosio Santiago |
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Affiliation: | Unitat de Bioquímica, Dep. Ciències Fisiològiques II, Facultat de Medicina, Campus Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, c/Feixa Llarga s/n., Barcelona, Spain. |
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Abstract: | Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accompanies apoptosis in the most proliferative, N-Myc overexpressing cells. In contrast, autophagy precedes apoptosis and acts as a protective mechanism in the less proliferative, non-N-Myc overexpressing cells. Therefore, the autophagy induction is a relevant event in the NB response to HDACis, and it should be considered in the design of new treatments for this malignancy. |
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Keywords: | Neuroblastoma HDACi Trichostatin A Apoptosis Autophagy |
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