Induced cell death and its role in hemopoietic hypoplasia after cytostatic treatment |
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Authors: | E. D. Gol'dberg G. V. Karpova E. A. Timina I. A. Khlusov |
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Affiliation: | (1) Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk |
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Abstract: | The morphological signs of apoptosis in the bone-marrow cells and thymocytes, indices of cellularity in these organs and in peripheral blood and the absolute number of committed bone marrow cells-precursors have been studied on CBA mice injected with Etoposid (1/2 LD50). The results of the study suggest that reduced cellular counts observed in the hemopoietic organs 3–6 h after the cytostatic injection are due to Etoposid-induced apoptosis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 39–42, January 1999 |
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Keywords: | Etoposid apoptosis morphology bone marrow thymus peripheral blood |
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