Induced cell death and its role in hemopoietic hypoplasia after cytostatic treatment

The morphological signs of apoptosis in the bone-marrow cells and thymocytes, indices of cellularity in these organs and in peripheral blood and the absolute number of committed bone marrow cells-precursors have been studied on CBA mice injected with Etoposid (1/2 LD₅₀). The results of the study suggest that reduced cellular counts observed in the hemopoietic organs 3–6 h after the cytostatic injection are due to Etoposid-induced apoptosis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 39–42, January 1999