| 何首乌颗粒对亚急性衰老大鼠睾丸PCNA表达的影响 |
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| 引用本文： | 齐聪儒,颜勇,陈志宏,庞晓静. 何首乌颗粒对亚急性衰老大鼠睾丸PCNA表达的影响[J]. 承德医学院学报, 2004, 21(2): 102-103 |
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| 作者姓名： | 齐聪儒 颜勇 陈志宏 庞晓静 |
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| 作者单位： | 承德医学院,河北,承德,067000;承德医学院,河北,承德,067000;承德医学院,河北,承德,067000;承德医学院,河北,承德,067000 |
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| 摘 要： | 目的:观察何首乌颗粒(Heshouwu Granule,HG)对亚急性衰老大鼠睾丸PCNA表达的影响.方法:D-半乳糖(D-gal)连续腹腔注射制作亚急性衰老大鼠模型,检测HG灌胃前后模型大鼠血清睾酮含量及睾丸生精细胞PCNA表达的变化情况.结果:D-半乳糖致亚急性衰老大鼠血清睾酮含量及睾丸PCNA阳性细胞率明显下降,与正常大鼠比较差异显著(P<0.05,P<0.01);经HG灌胃后,二者均升高接近正常水平,与模型大鼠相比有明显差异(P<0.05,P<0.01).结论:HG可提高亚急性衰老大鼠血清睾酮含量及睾丸生精细胞PCNA表达水平,具有一定的延缓衰老作用.
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| 关 键 词： | 何首乌颗粒 亚急性衰老 PCNA |
| 文章编号： | 1004-6879(2004)02-0102-02 |
| 修稿时间： | 2003-09-22 |
EFFECT OF HESHOUWU GRANULE ON PCNA EXPRESSION IN TESTES OF SUB-ACUTELY AGING RATS |
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| QI Cong ru,YAN Yong,CHEN Zhi hong,et al. EFFECT OF HESHOUWU GRANULE ON PCNA EXPRESSION IN TESTES OF SUB-ACUTELY AGING RATS[J]. Journal of Chengde Medical College, 2004, 21(2): 102-103 |
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| Authors: | QI Cong ru YAN Yong CHEN Zhi hong et al |
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| Abstract: | Objective:To study the effect of Heshouwu Granule (HG) on PCNA expression in testes of sub acutely aging rats.Methods: The sub acutely aging rats were made by injecting D gal into abdominal cavity continually. Then the testosterone level in serum and PCNA expression in testes were observed before and after taking HG. Results: The testosterone level in serum and PCNA expression in testes decreased significantly after injecting D gal continually compared with normal rats (P<0.05,P<0.01); these two indexes all increased obviously after taking HG compared with sub acutely aging rats (P<0.05,P<0.01). Conclusion: HG can increase the testosterone level in serum and PCNA expression in testes of sub acutely aging rats, HG has fairly effect on delaying senescence. |
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| Keywords: | PCNA |
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