| 上皮性卵巢癌中Skp2和P27蛋白的表达及临床意义 |
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| 引用本文： | 刘云春,魏荣英,李建平.上皮性卵巢癌中Skp2和P27蛋白的表达及临床意义[J].中国妇幼保健,2007,22(18):2570-2572. |
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| 作者姓名： | 刘云春 魏荣英 李建平 |
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| 作者单位： | 河北北方学院附属第一医院妇产科,河北,张家口,075000 |
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| 摘 要： | 目的:探讨Skp2和P27蛋白表达与上皮性卵巢癌发生、发展及预后评价的意义。方法:采用免疫组化法检测15例卵巢上皮性良性肿瘤、10例卵巢上皮性交界性肿瘤及58例上皮性卵巢癌中Skp2和P27蛋白的表达情况。结果:Skp2在卵巢上皮性良性及交界性肿瘤中的表达均为阴性,而在上皮性卵巢癌中高表达,阳性率为48.28%(28/58),Skp2在中低分化组、Ⅲ/Ⅳ期组及有淋巴结转移组分别高于高分化组(P<0.01)、Ⅰ/Ⅱ期组(P<0.01)及无淋巴结转移组(P<0.01)。在不同年龄及组织类型的卵巢癌中表达的差异无统计学意义。P27蛋白与Skp2蛋白在卵巢癌的表达呈负相关。结论:Skp2和P27蛋白在上皮性卵巢癌的发生、发展及预后中起重要作用,对卵巢癌的预后有意义。
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| 关 键 词： | 卵巢癌 Skp2 P27 临床分期 病理分级 |
| 文章编号： | 1001-4411（2007）18-2570-03 |
| 修稿时间： | 2006-03-19 |
Expression of Skp2 and P27 protein in ovarian epithelial tumors and its clinical significance |
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| LIU Yun-Chun,WEI Rong-Ying,LI Jian-Ping.Expression of Skp2 and P27 protein in ovarian epithelial tumors and its clinical significance[J].Maternal and Child Health Care of China,2007,22(18):2570-2572. |
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| Authors: | LIU Yun-Chun WEI Rong-Ying LI Jian-Ping |
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| Institution: | Department of Obstetrics and Gynecology, The first Affiliated Hospital of Hebei Beifang College, Zhangjiakou 075000, Hebei , China |
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| Abstract: | Objective:To investigate expression of Skp2 and P27 protein in ovarian epithelial tumors angits role. Methods:To measured 83 cases of ovarian epithelia tumor tissues with monoclonal antibody Skp2 and P27 by immunohistochemistry. Results:The rate of positive expression of Skp2 was 48.28% in ovarian epithelial cancers .No expression of the gene protein appeared in borderline and benign ovarian tumor tissues,Skp2 express inversely correlated with P27 protein in ovarian epithelial cancer.Conclusion:Skp2 and P27 gene participate in the origin and development of ovarian epithelial cancers,and estimate the prognosis of ovarian epithelial cancer patients. |
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| Keywords: | Skp2 P27 |
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