| 急性代谢性酸中毒时脑脊液Pco2升高的作用 |
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| 引用本文： | 金发光,钱桂生.急性代谢性酸中毒时脑脊液Pco2升高的作用[J].第四军医大学学报,1996,17(1):46-48. |
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| 作者姓名： | 金发光 钱桂生 |
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| 作者单位： | 第四军医大学唐都医院呼吸内科，第三军医大学新桥医院呼吸内科 |
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| 摘 要： | 动态观察犬急性代谢性酸中毒动脉血和脑脊液（ＣＳＦ）酸碱变量，结果发现，ｐＨａ和（ＨＣＯ３）迅速大幅度下降，而ＣＳＦｐＨ缓慢下降，且△ＣＳＦｐＨ〈△ｐＨａ，ＣＳＦ（ＨＣＯ＾－３）６ｈ仅下降了１．６ｍｍｏｌ／Ｌ（Ｐ〉０．０５），Ｐａｃｏ２保持正常，而ＣＳＦＰｃｏ２显著升高，说明ＣＳＦ（ＨＣＯ＾－３）相对稳定是ＣＳＦＰｃｏ２升高的结果，ＣＳＦＰｃｏ２升高的机制可能是在酸中毒时，血液中大量增加的Ｈ＾＋在脑
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| 关 键 词： | 急性病 代谢性 酸中毒 脑脊液 酸碱平衡 |
Role of the P CO 2 increase in cerebrospinal fluid in acute metabolic acidosis |
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| Jin Faguang ,Qian Guisheng ,Tang Minzhang ,Wang Lin.Role of the P CO 2 increase in cerebrospinal fluid in acute metabolic acidosis[J].Journal of the Fourth Military Medical University,1996,17(1):46-48. |
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| Authors: | Jin Faguang Qian Guisheng Tang Minzhang Wang Lin |
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| Institution: | Jin Faguang 1,Qian Guisheng 2,Tang Minzhang 1,Wang Lin 1 1Department of Respiratory Disease,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038 2Department of Respiratory Disease,Xinqiao Hospital,Third Military Medical Univ |
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| Abstract: | Acid base variables were dynamically observed in the arterial blood and cerebrospinal fluid (CSF) of a canine model with acute metabolic acidosis. It was found that when arterial pH and plasma level of bicarbonate ions (HCO - 3) registered a significant drop, CSF HCO - 3 concentration fell only 1.6 mmol/L after 6 h ( P >0.05), CSF P CO 2 increased markedly in spite of the constancy of arterial P CO 2 . The findings indicate that CSF HCO - 3 concentration depends upon CSF P CO 2 . The mechanism of this P CO 2 increase in CSF is based on the fact that accumulated H + in blood flows rapidly against the wall under the action of the brain capillary membrane potential and, buffered by HCO - 3, large amount of CO 2 results and diffuses in to CSF. |
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| Keywords: | acidosis metabolic cerebrospinal fluid acid base balance |
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