交沙霉素的抗菌作用及临床治疗各种细菌感染34例

本文测定了交沙霉素的体外抗菌作用。43株表皮葡萄球菌(表葡菌)和金黄色葡萄球菌(金葡菌)对交沙霉素和红霉素敏感率分别为81％和54％。交沙霉素对26株厌氧葡萄球菌(消化球菌)、消化链球菌和28株类杆菌的MIC_(50)分别为0.5和2mg/L。交沙霉素对34例口腔、五官及皮肤的感染全部有效,其中显效(痊愈)占88％。31例获细菌33株,细菌转阴率为97％。治疗中仅3例出现头晕和轻度消化道反应。

Antibacterial activity and clinical efficacy of josamycin in 34 patients with various infections

Antibacterial activity of josamycin was determined. Sensitivity rates of 43 strains of S.aurens and S.epidermidis for josamycin and erythromycin were 81% and 54% respectively. MIC50s of josamycin against 26 strains of Peptococcus and Pep-tostreptococcus, and 28 strains of Bacteroides were 0.5 and 2 mg/L respectively. Thirty-four patients with boils, nasal sinusitis, otitis or oral infection were treated with josamycin. Thirty patients were cured and 4 improved. Thirty three strains were isolated in 31 patients. The pathogen was eradicated in all but 1 patient. Mild dizziness, epigastric pain and nausea occurred one each in 3 patients .