| 生物信息学方法在判断DNA结合蛋白质和预测结合位点中的应用 |
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| 引用本文： | 刘子朋,章宏九,李雅晴,朱云蛟,胡健,方慧生.生物信息学方法在判断DNA结合蛋白质和预测结合位点中的应用[J].药学进展,2009,33(11):486-490. |
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| 作者姓名： | 刘子朋 章宏九 李雅晴 朱云蛟 胡健 方慧生 |
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| 作者单位： | 1. 中国药科大学生命科学与技术学院,江苏,南京,210009
2. 中国药科大学药学院,江苏,南京,210009 |
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| 摘 要： | 综述生物信息学方法在判断DNA结合蛋白质和预测结合位点中的应用研究进展。蛋白质与DNA间的相互作用是基因表达调控的分子生物学基础,因此DNA结合蛋白的判断以及DNA与蛋白质间作用位点的预测一直以来都是分子生物学和生物信息学的前沿领域。采用生物信息学方法进行这类判断和预测,具有省时、省力的特点,近年来吸引了众多科学家的关注。
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| 关 键 词： | 生物信息学 蛋白质-DNA相互作用 DNA结合蛋白 结合位点预测 |
The Application of Bioinformatical Method in Distinguishing the DNA-binding Protein and Predicting the Binding Site in Protein-DNA Interface |
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| LIU Zi-peng,ZHANG Hong-jiu,LI Ya-qing,ZHU Yun-jiao,HU Jian,FANG Hui-sheng.The Application of Bioinformatical Method in Distinguishing the DNA-binding Protein and Predicting the Binding Site in Protein-DNA Interface[J].Progress in Pharmaceutical Sciences,2009,33(11):486-490. |
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| Authors: | LIU Zi-peng ZHANG Hong-jiu LI Ya-qing ZHU Yun-jiao HU Jian FANG Hui-sheng |
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| Institution: | LIU Zi-peng, ZHANG Hong-jiu, LI Ya-qing, ZHU Yun-jiao, HU Jian, FANG Hui-sheng (1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China; 2. School of Phamacy, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | The research progress in application of bioinformatical method in distinguishing the DNA-binding protein from the other proteins and predicting the binding sites between DNA and protein was reviewed. C, enetie regulation is completed by protein-DNA interaction and therefore how to distinguish DNA-binding protein from the other proteins and further predict the binding sites between protein and DNA is always the frontier field in the molecular biology and bioinformatics. In this field, bioinformatical method which has certain features such as time-saving and labour-saving has attracted many scientists. |
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| Keywords: | bioinformatics protein-DNA interaction DNA-binding protein prediction of binding site |
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