| 淋巴瘤治疗中期^18F-FDG PET检查的临床应用价值 |
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| 引用本文： | 张红宇,孟庆祥,柳金,庞丽萍,王钧,许蕾,冯佳,张文丽,张倩,孙丽华,钟凤鸾,徐海婵,虞积仁.淋巴瘤治疗中期^18F-FDG PET检查的临床应用价值[J].中国临床医学,2009,16(2):309-311. |
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| 作者姓名： | 张红宇 孟庆祥 柳金 庞丽萍 王钧 许蕾 冯佳 张文丽 张倩 孙丽华 钟凤鸾 徐海婵 虞积仁 |
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| 作者单位： | 北京大学深圳医院血液科,广东深圳,518036 |
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| 摘 要： | 目的：探讨在淋巴瘤治疗中期^18氟-氟代脱氧葡萄糖-正电子发射计算机断层显像（fluorine-18 fluorodeoxyglucose positron emission tomography,^18F-FDP PET/CT）检查的临床应用价值。方法：回顾分析43例淋巴瘤患者治疗中期^18F-FDPPET/CT检测淋巴结和结外病变的结果,并与同期CT、B超影像结果进行比较,并结合淋巴结、骨髓活检及生化结果,评价其对早期临床疗效的评价和对预后的预测价值。结果：治疗中期^18F-FDP PET/CT共检测15例有残留病灶,此15例临床均未获得完全缓解。同期CT和B超检查29例共32处有残留肿块,除其中同时伴PET阳性的有9例全部复发,另20例得到完全缓解（HD5例,NHL15例）;另有8例PET和CT或B超均为阴性,期中2例复发;此外还对6例PET/CT显示阴性但CT、B超检查显示阳性患者的浅表淋巴结进行了2次活检,病理结果均显示为非淋巴瘤组织。比例风险模型（COX）分析显示中期PET阳性为疾病复发或进展的独立预后不良因素（P〈0.01）。结论：PET/CT对肿块性质判定较传统影像有显著的优势,治疗中期PET/CT检查对早中期疗效判断和临床预后有显著的临床意义。
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| 关 键 词： | 淋巴瘤 氟代脱氧葡萄糖 正电子发射计算机断层显像 |
Value of Midtreatment ~(18)F-FDP PET in Monitoring Response to Therapy and Prediction Outcome in Lymphoma |
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| ZHANG Hongyu,MENG Qinxiang,LIU Jin,PANG Liping,WANG Jun,XU Lei,FENG Jia,ZHANG Wenli,ZHANG Qian,SUN Lihua,ZHONG Fengruan,XU Haichan,YU Jiren.Value of Midtreatment ~(18)F-FDP PET in Monitoring Response to Therapy and Prediction Outcome in Lymphoma[J].Chinese Journal Of Clinical Medicine,2009,16(2):309-311. |
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| Authors: | ZHANG Hongyu MENG Qinxiang LIU Jin PANG Liping WANG Jun XU Lei FENG Jia ZHANG Wenli ZHANG Qian SUN Lihua ZHONG Fengruan XU Haichan YU Jiren |
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| Institution: | ZHANG Hongyu MENG Qinxiang LIU Jin PANG Liping WANG Jun XU Lei FENG Jia ZHANG Wenli ZHANG Qian SUN Lihua ZHONG Fengruan XU Haichan YU Jiren Department of Hematology,Peking University Shenzhen Hospital,Shenzhen 518036 |
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| Abstract: | Objective:To evaluate midtreatment 18F-FDP PET in monitoring response to therapy and prediction outcome in Lymphoma.Methods:Retrospective analysis forty-three patients with lymphoma who underwent FDG-PET scan after four cycles of chemotherapy, it was also compared with computed tomography(CT),B ultrasonic and bone marrow biopsy to investigate lymph node/extranodal manifestations. Results:After four cycles of chemotherapy,15 patients had positive FDG-PET and all of them progressed or relapsed, 9 of 26 patien... |
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| Keywords: | Lymphoma 18F-FDP PET/CT |
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