水盐控制对CAPD患者微炎症状态的影响

目的 了解水盐控制对持续不卧床腹膜透析（CAPD）患者徽炎症状态的影响。方法 选择在我院肾内科门诊随诊行标准CAPD的患者32例，实验组（n=16）以健康教育的形式指导患者进行严格的水盐摄人控制。对照组（n=16）自由进水、进食；实验3、6个月时抽血测定C反应蛋白（CRP）、白细胞介素-6（IL-6）、血清白蛋白（Alb）、胆固醇（CH）、甘油三酯（TG），并随访血压变化。结果 实验组6个月时CRP、IL-6较实验前有显著意义下降（P〈0．05），与相同时间对照组比较亦有明显差别（P〈0．05）；实验组血Alb6月时明显上升（P〈0．05），与相同时间对照组比较有显著差别（P〈0．01），TG、CH两组无明显意义改变（P〉0．05）。实验组的血压较对照组比较呈下降趋势。结论 严格的水盐控制能明显减轻CAPD患者的微炎症状态。机理可能与减轻容量负荷、改善营养不良有关。

Effect of controlling the intake of water and salt on microinflammation state in CAPD patients

Objective To investigate the effect of controlling the intake of water and salt on microinflammation state in CAPD patients. Methods Thirty-two patients following-up in our renal department with standard CAPD were divided into 2 groups randomly. The treatment group(n=16) was taught by our PD nurses that they should limit the intake of water and salt strictly and the control group's intake hadn't restriction. Measurement of the level of C reaction protein(CRP), interleukin-6(IL-6), albumin(Alb), Cholesterol(CH), triglyceride(TG) were performed before experiment and after 3, 6 months, at the same time took the blood pressure. Results The level of CRP and IL-6 in treatment group decreased significantly after 6 months(P<0.05) and there were significant differences compared with control group at the same time(P<0.05);The level of Alb increased after 6 month treatment(P<0.05, P<0.01); No significant changes of TG, CH were observed in two groups(P>0.05). The blood pressure decreased in some degree. Conclusions The strict controlling the intake of water and salt can significantly decrease the microinflammation state in CAPD patients.