| 替罗非班对急性冠脉综合征患者PCI术后MMP-9及IL-6水平的影响 |
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| 引用本文： | 顾晓龙,龚志华,邱健. 替罗非班对急性冠脉综合征患者PCI术后MMP-9及IL-6水平的影响[J]. 心脏杂志, 2011, 23(2): 235-237 |
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| 作者姓名： | 顾晓龙 龚志华 邱健 |
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| 作者单位： | 广州军区广州医院心血管内科，广东 广州 510010 |
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| 摘 要： | 目的: 观察替罗非班对急性冠脉综合征(ACS)患者经皮冠状动脉成形术(PCI)术后基质金属蛋白酶-9(MMP-9)及白介素-6（IL-6）水平的影响。方法: 选择我院2007年2月~2008年12月住院的ACS患者68例，随机分为对照组(n=34)和替罗非班组(n=34)。两组均急诊行PCI术，分别于PCI术前及术后12 h，用ELISA法检测患者血清MMP-9及IL-6的水平。结果: 替罗非班组与对照组相比,PCI术前两组之间MMP-9及IL-6的差异无统计学意义；PCI术后12 h，二者MMP-9的水平［(492±65) vs.(560±82)μg/L］和IL-6的水平［(46.0±7.2) vs.(59.7±8.2)ng/L］差异明显(P<0.05)。结论: 血小板GPⅡb/Ⅲa受体拮抗剂替罗非班能显著降低ACS患者介入术后MMP-9及IL-6的水平，抑制炎症反应，从而对血管具有一定的保护作用。
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| 关 键 词： | 替罗非班 急性冠脉综合征 基质金属蛋白酶-9 白介素-6 |
| 收稿时间： | 2010-04-05 |
Effect of tirofiban on levels of MMP-9 and IL-6 in acute coronary syndrome patients after percutaneous coronary intervention |
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| GU Xiao-long,GONG Zhi-hua,QIU Jian. Effect of tirofiban on levels of MMP-9 and IL-6 in acute coronary syndrome patients after percutaneous coronary intervention[J]. Chinese Heart Journal, 2011, 23(2): 235-237 |
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| Authors: | GU Xiao-long GONG Zhi-hua QIU Jian |
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| Affiliation: | GU Xiao-long,GONG Zhi-hua,QIU Jian(Department of Cardiology,General Hospital,Guangzhou Military Area Command,Guangzhou 510010,Guangdong,China) |
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| Abstract: | AIM: To investigate the effect of tirofiban on the levels of MMP-9 and IL-6 in acute coronary syndrome(ACS) patients after percutaneous coronary intervention(PCI).METHODS: A total of 68 ACS patients in our hospital from February 2007 to December 2008 were randomly divided into tirofiban group(n=34) and control group(n=34).All patients received emergency PCI.Venous blood samples were taken before and 12 h after PCI in both groups and serum samples were analyzed for MMP-9 and IL-6 by ELISA method.RESULTS: No ... |
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| Keywords: | tirofiban acute coronary syndrome MMP-9 IL-6 |
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