| 非缝合式无支架异种主动脉生物瓣膜的研制 |
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| 引用本文： | 徐驰,曹燕飞,陈炜生,姜淑云,陈龙,盛继红,李慧忠. 非缝合式无支架异种主动脉生物瓣膜的研制[J]. 心脏杂志, 2011, 23(2): 250-254 |
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| 作者姓名： | 徐驰 曹燕飞 陈炜生 姜淑云 陈龙 盛继红 李慧忠 |
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| 作者单位： | 1.解放军总医院胸外科，北京 100853；2.南京军区福州总医院心胸外科，福州 350025；3.陕西省人民医院心胸外科，陕西 西安 710061；4.南京医科大学附属无锡市人民医院重症监护科，江苏 无锡 214023 |
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| 基金项目： | 福建省自然科学基金面上项目资助(2007J0109) |
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| 摘 要： | 目的: 研制新型非缝合式无支架异种主动脉生物瓣膜，在体外对其功能进行初步研究。方法: 将猪主动脉瓣缝合到NiTi形状记忆合金支架上，在离体猪心脏内置入新型瓣膜，肉眼及彩超下观测瓣膜闭合、冠状动脉血流及瓣周漏情况。通过TH-1200型人工心脏瓣膜脉动流测试系统测定25#非缝合式无支架异种主动脉生物瓣膜平均跨瓣压差、返流百分比、瓣膜开口面积。结果: 新型瓣膜能较简单的植入离体猪心脏内。且不同压力（80～250mmHg）下，瓣膜闭合良好，无明显瓣周漏，冠状动脉血流良好；心脏彩超检测瓣周结构与主动脉壁之间可见无回声间隙，无明显的瓣周漏。体外脉动实验提示新型瓣膜与机械瓣膜相比跨瓣压差小，返流少，开口面积大。结论: 该型瓣膜制备相对简单，具有血流动力学良好，跨瓣压小，无需抗凝等优点，可简化手术操作，降低手术难度。
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| 关 键 词： | 异种主动脉生物瓣膜，无支架，非缝合式 脉动流实验 |
| 收稿时间： | 2010-05-12 |
Research on sutureless and stentless heterologous aortic bioprosthesis |
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| XU Chi,,CAO Yan-fei,CHEN Wei-sheng,JIANG Shu-yun,CHEN Long,SHENG Ji-hong,LI Hui-zhong. Research on sutureless and stentless heterologous aortic bioprosthesis[J]. Chinese Heart Journal, 2011, 23(2): 250-254 |
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| Authors: | XU Chi CAO Yan-fei CHEN Wei-sheng JIANG Shu-yun CHEN Long SHENG Ji-hong LI Hui-zhong |
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| Affiliation: | XU Chi1,2,CAO Yan-fei3,CHEN Wei-sheng2,JIANG Shu-yun4,CHEN Long2,SHENG Ji-hong2,LI Hui-zhong2(1.Department of Thoracic Surgery,PLA General Hospital,Beijing 100853,China,2.Department of Cardiothoracic Surgery,Fuzhou General Hospital,Fuzhou 350025,Fujian,3.Department of Cardiothoracic Surgery,Shaanxi Provincial People's Hospital,Xi'an 710061,Shaanxi,4.ICU,Affiliated Wuxi People's Hospital,Nanjing Medical University,Wuxi 214023,Jiangsu,China) |
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| Abstract: | AIM: To devise a new sutureless and stentless heterologous aortic bioprosthesis and to test the function of the new valve in vitro.METHODS: The pig aortic valve was sewn in the NiTi shape memory alloy stent and the new valve was then inserted in a pig heart in vitro.Valve closure,coronary blood flow and parabasilar leak were observed by the naked eye and color Doppler ultrasound.New type valves(#25) and mechanical valves(#25) were tested and compared by TH-1200 H.V.Prosthesis Pulsatile Flow Tester in vitro.... |
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| Keywords: | heterologous aortic bioprosthesis stentless sutureless pulsatile flow testing |
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