| 激活PKC降低TAC大鼠肥大心脏的收缩功能 |
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| 引用本文： | 张蓝宁,张琳,王云英,陈焱,常惠,余志斌.激活PKC降低TAC大鼠肥大心脏的收缩功能[J].心脏杂志,2011,23(2):184-188. |
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| 作者姓名： | 张蓝宁 张琳 王云英 陈焱 常惠 余志斌 |
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| 作者单位： | 第四军医大学航空航天生理学教研室， 陕西 西安 710032 |
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| 基金项目： | 国家自然科学基金资助课题(30700264) |
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| 摘 要： | 目的: 探究心肌细胞肥大过程中，蛋白激酶C(PKC)激活与心肌收缩功能的关系。方法: 用12只雄性SD大鼠原则随机均分为A、B组，A组行腹主动脉缩窄(transverse abdominal aortic constriction，TAC)制备高血压大鼠模型，B组作为对照组,分别术后饲养16周。采用离体工作心脏灌流装置对16周的大鼠心脏进行灌注，同时行左心室内Millar导管插管，监测心功能的各项指标。结果: TAC可引起大鼠的血压显著增高，心肌肥厚，心输出量增多，呈代偿状态。PKC激动剂佛波酯(PMA)可使TAC大鼠的心输出量显著减少，心肌收缩与舒张时间延长，并降低舒张速率。由于收缩与舒张时程延长，舒张速率降低，在高心率下可导致左心室舒张末压抬高，心脏泵血功能大幅降低。结论: PMA可激活16周的TAC大鼠肥大心肌细胞中的PKCs，降低肥大心肌收缩功能，这可能为引起心力衰竭的原因之一。
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| 关 键 词： | 蛋白激酶C 佛波酯 主动脉缩窄 心肌肥厚 心力衰竭 大鼠 |
| 收稿时间： | 2010-05-28 |
Activation of protein kinase-C reduces contractile function of hypertrophic heart in transverse aortic constriction rats |
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| ZHANG Lan-ning,ZHANG Lin,WANG Yun-ying,CHEN Yan,CHANG Hui,YU Zhi-bin.Activation of protein kinase-C reduces contractile function of hypertrophic heart in transverse aortic constriction rats[J].Chinese Heart Journal,2011,23(2):184-188. |
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| Authors: | ZHANG Lan-ning ZHANG Lin WANG Yun-ying CHEN Yan CHANG Hui YU Zhi-bin |
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| Institution: | ZHANG Lan-ning,ZHANG Lin,WANG Yun-ying,CHEN Yan,CHANG Hui,YU Zhi-bin(Department of Aerospace Physiology,Fourth Military Medical University,Xi'an 710032,Shaanxi,China) |
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| Abstract: | AIM: To observe the effects of protein kinase-C(PKC) on the contractile function of hypertrophic hearts in transverse abdominal aortic constriction(TAC) rats in order to demonstrate whether PKC contributes as a pivotal node during the transition from cardiac hypertrophy to heart failure.METHODS: Twenty-four male Sprague Dawley rats were randomly divided into control and TAC groups.After 16 weeks,the hearts were rapidly removed and working-heart perfusion system and Millar probe were applied to monitor cardi... |
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| Keywords: | phorbol myristate acetate protein kinase C transverse abdominal aortic constriction rats cardiac hypertrophy heart failure |
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