Lack of Relationship Between Chronic Upper Abdominal Symptoms and Gastric Function in Functional Dyspepsia |
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Authors: | Niels van Lelyveld Maria Schipper Melvin Samsom |
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Affiliation: | (1) Department of Gastroenterology, Gastrointestinal Research Unit, University Medical Centre Utrecht, PO Box 85500, 3508, GA, Utrecht, The Netherlands;(2) Centre of Biostatistics, University of Utrecht, Utrecht, The Netherlands |
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Abstract: | To determine the relationship between gastric function and upper abdominal sensations we studied sixty FD patients (43 female). All patients underwent three gastric function tests: 13C octanoic gastric emptying test, three-dimensional ultrasonography (proximal and distal gastric volume), and the nutrient drink test. Upper abdominal sensations experienced in daily life were scored using questionnaires. Impaired proximal gastric relaxation (23%) and a delayed gastric emptying (33%) are highly prevalent in FD patients; however, only a small overlap exists between the two pathophysiologic disorders (5%). No relationship was found between chronic upper abdominal symptoms and gastric function (proximal gastric relaxation, gastric emptying rate, or drinking capacity) (all P > 0.01). Proximal gastric relaxation or gastric emptying rate had no effect on maximum drinking capacity (P > 0.01). The lack of relationship between chronic upper abdominal sensations and gastric function questions the role of these pathophysiologic mechanisms in the generation of symptoms. |
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Keywords: | Functional dyspepsia Stomach Gastric emptying 3D-ultrasonography Nutrient drink test Upper abdominal symptoms |
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