Antagonistic effects of caffeine and yohimbine in animal tests of anxiety |
| |
| Authors: | H A Baldwin A L Johnston S E File |
| |
| Affiliation: | Department of Pharmacology, School of Pharmacy, University of London, U.K. |
| |
| Abstract: | The effect of a combination of caffeine and yohimbine was investigated in the social interaction, elevated plus-maze and punished-drinking tests of anxiety. Caffeine (40 mg/kg i.p.) had anxiogenic-like effects in the social interaction and plus-maze tests. Yohimbine (2.5 mg/kg i.p.) was anxiogenic-like in the plus-maze and displayed anticonflict activity. Unexpectedly, caffeine and yohimbine antagonized each others' effects in the social interaction and elevated plus-maze tests. |
| |
| Keywords: | |
|
|
