Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study |
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Authors: | Tomohiro Okura Tuomo Rankinen Jacques Gagnon Suzanne Lussier-Cacan Jean Davignon Arthur S. Leon D. C. Rao James S. Skinner Jack H. Wilmore Claude Bouchard |
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Affiliation: | (1) Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA;(2) Marine Biotechnology Research Centre, Remouski, Quebec, Canada;(3) Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada;(4) Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA;(5) Division of Biostatistics and Departments of Genetics and Psychiatry, Washington University Medical School, St Louis, MO, USA;(6) Department of Kinesiology, Indiana University, Bloomington, IN, USA;(7) Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA |
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Abstract: | We investigated whether regular aerobic exercise could affect plasma total homocysteine (tHcy), and whether there were sex-related or racial differences in tHcy changes. Data were available for 816 black and white men and women, aged 17–65 years, 711 of whom completed a 20 week aerobic exercise training program. The tHcy concentration was measured in frozen plasma samples by an HPLC method. In Blacks, tHcy did not change with exercise training [men −0.5 (SD 3.7) μmol/l, women 0.0 (2.2) μmol/l) but increased significantly in Whites (men +0.3 (1.7) μmol/l, women +0.2 (1.6) μmol/l). No sex-related differences were found in either racial group. Changes in tHcy correlated negatively with baseline homocysteine (r = −0.40, P < 0.0001). Homocysteine levels of the “High” (hyperhomocysteinemia) (≥15 μmol/l) group (n = 30) decreased significantly with regular aerobic exercise from 23.1 (12.1) to 19.6 (7.6) μmol/l. Homocysteine levels of the “Normal” group increased slightly from 8.2 ± 2.2 to 8.5 ± 2.4 μmol/l. Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range. |
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Keywords: | Aerobic exercise training Sex Homocysteine Hyperhomocysteinemia Racial differences |
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