| 脑心通对大鼠脑缺血海马CA1区神经元损伤的保护作用 |
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| 引用本文： | 朱心红,杨建明,高天明. 脑心通对大鼠脑缺血海马CA1区神经元损伤的保护作用[J]. 南方医科大学学报, 2004, 24(10): 1123-1125 |
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| 作者姓名： | 朱心红 杨建明 高天明 |
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| 作者单位： | 南方医科大学生理学教研室,广东,广州,510515;南方医科大学生理学教研室,广东,广州,510515;南方医科大学解剖学教研室,广东,广州,510515 |
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| 基金项目： | 国家自然科学基金(30125013,30330240,30371772),广东省自然科学基金(37047),教育部“长江学者”奖励计划~~ |
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| 摘 要： | 目的研究脑心通、中风回春丸对大鼠前脑缺血海马CA1区神经元损伤的保护作用。方法采用改良的Pulsinelli四血管闭塞法制作前脑缺血模型,光镜下观察并计CA1区存活锥体细胞密度;并与尼莫地平对照。结果脑心通及尼莫地平灌胃给药组大鼠海马CA1区存活锥体细胞密度明显高于生理盐水组(P<0.05,P<0.001),但脑心通与尼莫地平组之间无明显差异;中风回春丸无明显的神经保护作用。结论脑心通具有明显的神经保护作用。
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| 关 键 词： | 脑心通 中风回春丸 尼莫地平 海马 脑缺血 神经元/病理学 |
| 文章编号： | 1000-2588(2004)10-1123-03 |
| 修稿时间： | 2004-04-10 |
Neuroprotective effects of Naoxintong against neuronal injury in hippocampal CA1 region following transient forebrain ischemia in rats |
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| ZHU Xin-hong,YANG Jian-ming,GAO Tian-ming,Departments of Physiology and Anatomy,Southern Medical University,Guangzhou ,China. Neuroprotective effects of Naoxintong against neuronal injury in hippocampal CA1 region following transient forebrain ischemia in rats[J]. Journal of Southern Medical University, 2004, 24(10): 1123-1125 |
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| Authors: | ZHU Xin-hong YANG Jian-ming GAO Tian-ming Departments of Physiology Anatomy Southern Medical University Guangzhou China |
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| Affiliation: | ZHU Xin-hong1,YANG Jian-ming1,GAO Tian-ming1,2Departments of Physiology1 and Anatomy2,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To examine the neuroprotective effects of Naoxintong and Zhongfenghuichunwan on neuronal injury in CA1 region of rat hippocampus following transient forebrain ischemia. Methods Transient rat forebrain ischemia for 15 min was induced by modified four-vessel occlusion method. The density of survived pyramidal cells (neurons per 1 mm linear length) in CA1 region of the hippocampus was measured under light microscope. Results In Naoxintong or nimodipine-treated rats, the density of survived pyramidal cells in CA1 region was significantly greater than that of saline group (P<0.05, P<0.001, respectively), but oral administration of Zhongfenghuichunwan had no obvious effect on ischemia-induced neuronal damage in CA1 region. Conclusion Naoxintong can protect CA1 neurons against ischemic insult in rats. |
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| Keywords: | Naoxintong Zhongfenghuichunwan nimodipine hippocampus cerebral ischemia neurons/pathology |
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