氨茶碱与纳洛酮联合用药方案治疗新生儿呼吸暂停的临床疗效分析

目的研究氨茶碱与纳洛酮联合用药治疗新生儿呼吸暂停的临床疗效。方法将84例患者随机分成两组,即对照组和实验组,每组42例,对照组采用氨茶碱治疗,首次剂量为5mg/kg,静脉滴注,减量维持2.5mg/kg持续静脉滴注,实验组在对照组基础上加用纳洛酮0.1mg/kg,静脉缓慢滴注,与氨茶碱交替使用,直至呼吸暂停明显改善,治疗结束后比较两组患者的总有效率和呼吸暂停的发生次数、发作持续时间、症状消失时间。结果实验组总有效率高于对照组(95.24%VS76.19%),两组比较差异有统计学意义(P<0.05);治疗结束后实验组患者的呼吸暂停发生次数、发作持续时间、症状消失时间均少于对照组,两组比较差异有统计学意义(P<0.05)。结论氨茶碱与纳洛酮联合应用治疗新生儿呼吸暂停取得较好的临床效果,优于单独应用氨茶碱的疗效,无明显的不良反应,利于患者的早日康复。

The Analysis of the Clinical Efficacy for Aminophylline and Naloxone Combination Therapy in the Treatment of Neonatal Apnea

Objective To study the clinical efficacy for aminophylline and naloxone combination therapy in the treatment of neonatal apnea.Methods 84 patients were randomly divided into two groups,the control group and the experimental group（n = 42 cases）.The control group was taken with aminophylline treatment,and the first dose was of 5mg/kg.Take for intravenous infusion,and the reduction was maintaining at 2.5 mg/kg with continuous intravenous infusion.The experimental group was taken with naloxone 0.1mg/kg on the basis of the control group.Slow intravenous infusion was taken,and aminophylline were used interchangeably,until apnea improved significantly.The treatment efficiency and the occurrence of apnea,duration of attack,the symptoms disappear time for the two groups were compared after treatment.Results The total efficiency rate in the experiment group was higher than that in the control group（95.24% VS76.19%）,the difference was statistically significant（P〈0.05）.After treatment,the apnea occurrence,duration of attack,the symptoms disappearance time in the experiment group were less than the control group,the difference was statistically significant（P〈0.05）.Conclusion The aminophylline and naloxone combination in the treatment of neonatal apnea obtains a better clinical results,it is superior to the effect of used aminophylline alone.There are no obvious side effects,and it is beneficial to the patient＇s speedy recovery.