儿童和成人的Hp相关性胃炎病理变化的对比研究

目的为了解成人和儿童各个年龄阶段人群感染Hp后的胃粘膜病理变化特点及探索其可能的发病机制。方法对313例成人和儿童Hp相关性胃炎病人的胃粘膜病理作了回顾性分析。结果儿童Hp相关性胃炎的病理变化以浅表性炎症为主，而在成人年龄越大，萎缩性胃炎的比例越高，两者比较差异显著(X=40.3967，P<0.005)。成人组胃粘膜炎症中中性白细胞的比例明显高于儿童组。胃粘膜固有腺体萎缩和肠上皮化生也明显高于儿童组(U

Comparative study of pathologic changes in pediatric and adult patients with Hp-associated gastritis

Objective To study the pathologic and mechanism of changes of gastric mucosa in adult and pediatric patients after Hp infection. Methods Retrospective analysis of 313 cases of adult and pediatric Hp-associated gastritis was performed. Results Superficial inflammation was the main pathologic change in pediatric Hp-associated gastritis, but in adult, atrophic gastritis became more common, there was significant difference between the two(X =40. 3967, P < 0. 005). The proportion of neutrophilic infiltration in adult gastric mucosa was significantly higher thanthat in children, so were the intestinal metaplasia and glandular atrophy. (U * = 11. 079, P = 0. 001; U** = 4.2169, P =0.001). Conclusion Pathologic changes after Hp infection are closely related with age of the patient, with aadvancing agemore severe inflammation,mucosal atrophy and intestinal metaplasia can occur. (Shanghai Med J, 2001,24:105-107)