The HIV gp120-CD4 interaction: A target for pharmacological or immunological intervention? |
| |
| Authors: | John P. Moore Raymond W. Sweet |
| |
| Affiliation: | (1) Aaron Diamond AIDS Research Center, New York University School of Medicine, 455 First Avenue, 10016 New York, NY, USA;(2) Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, PO Box 1539, 19406 King of Prussia, PA, USA |
| |
| Abstract: | Summary The gp120-CD4 interaction is the initial stage in the infection cycle of CD4+ cells by HIV. It is therefore a logical target for pharmacological or immunological intervention. We review what is known about the gp120-CD4 binding reaction and the structures of the interacting ligands. We then discuss previous attempts to inhibit this interaction using antibodies and drugs, assess why such attempts have failed so far in vivo, and suggest future strategems. |
| |
| Keywords: | HIV gp120 CD4 gp120-CD4 interaction Anti-gp120 antibodies HIV pharmacology HIV therapy |
| 本文献已被 SpringerLink 等数据库收录！ |
|
