螺旋腺瘤临床病理分析

目的:对螺旋腺瘤的临床病理形态学特点、诊断和鉴别诊断、治疗及预后等进行初步探讨.方法:标本采用常规石蜡切片,HE染色.另对石蜡切片采用EnVision免疫组化二步法染色.结果:患者男性及女性各4例,发病年龄28～66岁,平均年龄40.1岁.8例肿瘤均表现为皮下小结节伴疼痛,结节大小0.3～1.5 cm.镜下见瘤细胞巢主要由两种类型的细胞构成:一型为基底样细胞,位于瘤细胞巢的周边;另一型为腺上皮样细胞,位于瘤细胞巢的中央.8例中有2例术后随访2～3年,均无复发.结论:螺旋腺瘤可见于全身各处皮下,常为单发性伴疼痛.肿瘤大多数为良性,免疫组化见瘤细胞巢周边的基底样细胞表达肌上皮标记阳性,中央的腺上皮样细胞表达腺上皮标记阳性.

Clinicopathological analysis of the spiradenoma

Objective To explore the pathological and morphological features,pathological diagnosis,differential diagnosis,therapy and prognosis of the spiradenoma(SA).Methods Eight cases of the spiradenoma were studied by using paraffin slice for HE staining and immunohischemistrical method(EnVision method).Results 8 patients aged from 28 to 66 years,averaging 40.1 years old,4 cases of each genda,showed small nodules beneath skin accompanied with pain.The size of nodules ranged from 0.3 cm to 1.5 cm.Under microscope,two distinct types of neoplasm epithelial cells could be seen,namely,the dark cells and the pale cells.The dark cells were basaloid cells and located at the periphery of the neoplasm cell nests,whereas,the pale cells were glandular epithelia cells and tended to situate in the center of the nests.Two of the 8 cases were followed-up for 2-3 years.No evidence of recurrence was found for the two cases.Conclusions Spiradenoma usually appeared as a solitary nodule with tenderness and located deeply in cutis at any region of the body.Spiradenoma is commonly benign.By immunochemistry stain,the basaloid cells are myoepithelium markers positive,and the glandular epithelia cells are glandular epithelium markers positive.