| 外周血淋巴细胞和肿瘤细胞体外化疗药敏相关性研究 |
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| 引用本文： | 袁淑兰,姜曙.外周血淋巴细胞和肿瘤细胞体外化疗药敏相关性研究[J].华西医科大学学报,2000,31(3):338-340. |
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| 作者姓名： | 袁淑兰 姜曙 |
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| 作者单位： | [1]华西医科大学附属第一医院肿瘤研究所,成都 [2]附属第一医院外科,成都 |
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| 摘 要： | 采用ＭＴＴ法体外药敏试验，检测了３５例神经胶质瘤患者外周血淋巴细胞和肿瘤细胞对１５种临床常用化疗药物的敏感性。结果：神经胶质瘤患者外周血淋巴细胞和肿瘤细胞对ＶＭ－２６和ＴＡＸ较敏感，对ＤＤＰ，Ｍｅ－ＣＣＮＵ，ＥＡＤＭ，ＡＤＭ，ＭＭＣ，ＨＣＰＴ等敏感，对ＭＴＸ，ＡＣＲ，ＶＰ－１６，ＶＣＲ，ＢＬＭ则不敏感。患者外周血淋巴细胞和肿瘤细胞对上述化疗药物的敏感率无显著性差异（Ｐ〉０．０５），以上结果提示，肿
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| 关 键 词： | 外周血淋巴细胞 肿瘤细胞 药物敏感试验 MTT法 |
Study on chemosensitivity assay in vitro in the peripheral blood lymphocyte and the tumor cells] |
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| S Yuan,Y Wang,S Jiang,Y Yang,Y Song,X Chen,C Tu.Study on chemosensitivity assay in vitro in the peripheral blood lymphocyte and the tumor cells][J].Journal of West China University of Medical Sciences,2000,31(3):338-340. |
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| Authors: | S Yuan Y Wang S Jiang Y Yang Y Song X Chen C Tu |
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| Institution: | Institute of Cancer Research, First Affiliated Hospital, WCUMC, Chengdu 610041. |
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| Abstract: | In this study, the MTT method was used to test the sensitivity of the peripheral blood lymphocyte and the tumor cells of 35 patients with neuroglioma to 15 kinds of anti-cancer drugs. The results showed that the peripheral blood lymphocyte and the tumor cells were more sensitive to chemotherapeutic drugs Vm26 and TAX, and sensitive to DDP, Me-CCNU, EADM, ADM, MMC, HCPT, but not sensitive to MTX, ACR, VP-16, VCR and BLM. There were no statistical differences in the rate of sensitivity to the above-mentioned drugs between the peripheral blood lymphocyte and the tumor cells. These results prompt that the chemosensitivity test of the peripheral blood lymphocyte may take the place of the tumor cells for reference to choosing chemotherapeutic drugs in clinical practice. |
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