Evidence for effectiveness of botulinum toxin for hyperhidrosis |
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Authors: | R Bhidayasiri D D Truong |
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Institution: | (1) Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn Univerisity Hospital, Bangkok, Thailand;(2) Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;(3) The Parkinson’s and Movement Disorder Institute, Fountain Valley, CA, USA |
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Abstract: | Summary Hyperhidrosis refers to excessive and uncontrollable sweating beyond that is required to return body temperature to normal.
Although a broad spectrum of treatment modalities are available including topical and systemic therapies, iontophoresis, and
surgical interventions, their efficacy are usually short-term or are associated with unacceptable side effects.
Recently, chemodenervation using botulinum toxin has emerged as a safe and effective treatment for both primary palmar and
axillary hyperhidrosis in several clinical trials. In this article, we utilized the scale developed by the Therapeutics and
Technology Assessment (TTA) subcommittee of the American Academy of Neurology evaluating current evidence supporting the use
of botulinum toxin for the treatment of primary focal hyperhidrosis. As a result, there is a strong evidence to support the
efficacy of botulinum toxin type A in axillary (Level A evidence) and palmar (Level B evidence) hyperhidrosis.
Correspondence: Roongroj Bhidayasiri, MRCP (UK), Chulalongkorn Comprehensive Movement Disorders Center, Division of Neurology,
Chulalongkorn University Hospital, Bangkok 10330, Thailand |
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Keywords: | : Botulinum toxin hyperhidriosis |
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