HTK和St.Thomas液在复杂先天性心脏病长时间心肌缺血心肺转流中的应用

目的 比较两种心肌保护液在患儿复杂先天性心脏病手术中的心肌保护效果.方法 40例复杂先天性心脏病患儿随机分为两组,分别应用St.Thomas液(T组,25 ml/kg,每25～30分钟复灌)和HTK液(H组,40 ml/kg,4～6 min灌注完毕.主动脉阻断时间超过3 h复灌),每组20例.观察患儿复苏情况,阻断前、停心肺转流(CPB)后肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)正性肌力药物的使用及ICU停留时间.结果 两组CPB时间及主动脉阻断时间差异无统计学意义.两组均自动复跳,H组术后心肌酶的变化明显小于T组(P＜0.05或P＜0.01).术后正性肌力药物的使用时间H组明显短于T组(P＜0.05).结论 HTK液具有较好的心肌保护效果,单次灌注对于长时间缺血心肌的保护安全有效,切实可行.

A clinical comparative study between HTK and St.Thomas solution in infant with complex CHD undergoing long term cardiopulmonary bypass

Objective To compare the myocardial protective effects of HTK and St.Thomas solution.Methods A consecutive series of 40 infants undergoing long-term cardiopulmonary bypass(CPB)was divided randomly into two groups with 20 cases each,in which St.Thomas solution(group T,25 ml/kg perfused every 25 min)or HTK solution(group H,40 ml/kg perfused in 4-6 min and repeated 3 h later)was used.The CK,CK-MB,time to extubation and ICU-stay were observed.Results The CK and CK-MB were higher in group T than those in group H...