乳腺癌MR动态增强与预后因子的相关性研究

目的探讨MR动态增强(DCE-MRI)活体评估乳腺癌预后的可行性。资料与方法分析DCE-MRI参数与乳腺癌分子预后因子的相关性,对34例乳腺癌患者术前行DCE-MRI检查,病理组织免疫组织化学染色记录分子预后因子ER、Ki-67、c-erbB-2、uPA/PAI-1的表达情况,用Spearman等级相关分析分析时间-信号强度曲线、动态增强参数(强化率、峰值时间、初始斜率、流出率)与预后因子的相关性。结果曲线类型与uPA/PAI-1阳性表达呈正相关(r=0.507);峰值时间与ER阳性表达呈正相关(r=0.532),与Ki-67(r=-0.542)、c-erbB-2(r=-0.535)、uPA/PAI-1(r=-0.640)阳性表达呈负相关。结论部分DCE-MRI参数与乳腺癌预后因子表达具相关性,可以间接预测乳腺癌的预后,从而指导临床治疗方案的制定。

Correlation of Dynamic MR Features with Prognostic Factors in Breast Cancer

Objective To explore the possibility of kinetic MR parameters to predict the prognosis of breast cancer in vivo by dynamic CE MR imaging.Materials and Methods Thirty four patients with breast cancer underwent dynamic contrast enhanced MR imaging before operation.The type of time signal intensity curve(TIC) and the kinetic enhancing parameters(enhancement ratio,E1-6;time to peak,Tpeak;the initial slope,Slopei and the washout ratio,Wpeak-6) were recorded.The correlation between them and detected biomarkers(ER,c-erbB-2,Ki-67,uPA/PAI-1),were statistically analyzed with the spearman rank correlation.Results The type of TIC correlated positively with the expression of uPA/PAI-1(r=0.507).The Tpeak correlated negatively with the expression of Ki-67(r=-0.542),c-erbB-2(r=-0.535)and uPA/PAI-1(r=-0.640).It also correlated positively with the expression of ER(r=0.532).Conclusion Some dynamic parameters of DCE MRI are useful in evaluating the prognosis and drawing up the treatment plan of the breast carcinoma in vivo.