儿童血源性感染患者病原菌菌群分布及耐药性分析 |
| |
引用本文: | 刘红娟,张良祺,查巍,程邦宁,鲁显福. 儿童血源性感染患者病原菌菌群分布及耐药性分析[J]. 安徽医药, 2014, 0(8): 1566-1568 |
| |
作者姓名: | 刘红娟 张良祺 查巍 程邦宁 鲁显福 |
| |
作者单位: | 刘红娟 (安徽省儿童医院检验中心,安徽 合肥,230051); 张良祺 (安徽省儿童医院检验中心,安徽 合肥,230051); 查巍 (安徽省儿童医院检验中心,安徽 合肥,230051); 程邦宁 (安徽省儿童医院检验中心,安徽 合肥,230051); 鲁显福(安徽医科大学麻醉教研室,安徽 合肥,230032); |
| |
摘 要: | 目的了解2012年住院患儿血培养中分离的病原菌分布及耐药状况,为血源性感染患儿的临床诊治与流行病学特征提供用药依据。方法回顾性分析该院导致血源性感染的663株病原菌分布及其抗菌药物耐药情况。结果 6 333份血培养标本分离出病原菌663株,阳性率10.5%;其中革兰阳性球菌404株占60.9%,包括凝固酶阴性葡萄球菌、金黄色葡萄球菌、肠球菌属;革兰阴性杆菌253株占38.2%,主要包括阴沟肠杆菌、铜绿假单胞菌、木糖氧化产碱杆菌、嗜麦芽窄食假单胞菌等;真菌6株占0.9%。药敏试验检出革兰阳性球菌对万古霉素、利奈唑胺敏感,对青霉素、红霉素、氨苄西林〉90%以上耐药;革兰阴性杆菌未发现耐亚胺培南菌株。结论儿童血液感染患者菌种较复杂,革兰阳性球菌是引起菌血症的主要病原菌,药敏结果提示检出菌株耐药性较强,因此需要根据血液感染细菌的分布特性和耐药性,选择敏感的抗生素治疗血源性感染患儿。
|
关 键 词: | 血流感染 细菌分布 耐药性 儿童 |
Distribution and drug-resistance of pathogens caused by bloodstream infections in children patients |
| |
Affiliation: | LIU Hong-juan,ZHANG Liang-qi,ZHA Wei, et al (Clinical Laboratory Center ,Anhui Provincial Children's Hospital ,Hefei ,Anhui 230051 ,China) |
| |
Abstract: | Objective To analyze the distribution and resistance of pathogens in blood culture species,so as to examine the clinical and epidemiological features of nosocomial bloodstream infectious(BSIS)-caused Gram-positive pathogens species,which were found in Anhui Provincial Children's Hospital from 1 Jan 2012 through 31 Dec 2012. Methods Distribution and resistance of 663 isolates were restropectively studied. Results Six hundred and sixty-three strains of pathogenic bacteria were separated from the specimens of 6333blood culture samples in our hospital. The positive rate was 10. 5%. Of these strains 404(60. 9%) were Gram-positive bacteria,including CONS,Staphylocosaureus,Enterococci,253(38. 2%) were Gram-negtive bacteria,including E. cloacae,P. aeruginosa,A. xylosoxidans,S. maltophilia,and 6(0. 9%) were fungus. Gram-positive bacillis was sensitive to Vancomyc and Linezolid. Compared with children patients with nosocomial bloodstream infection caused by other Gram-negative pathogens,90% resistant to ≥3 classes of amtimicrobials and were considered to be multidrug resistant including anti-imipenem isolates. Conclusions The resurgence of gram-positive bacteria is the predominant cause of nosocomical infectious pathogens in children patients in our hospital. Many Gram-positive cocci are now resistant to commonly used antibiotics. Therefore,newer,more effective antimicrobial therapies are needed to treat bloodstream infections according to the distribution and resistant of BSIS. |
| |
Keywords: | BSIS pathogens drug resistance children |
本文献已被 CNKI 维普 等数据库收录! |
|