小剂量持续服用他达拉非对糖尿病性勃起功能障碍的疗效观察

目的探讨和观察糖尿病性勃起功能障碍患者采用小剂量持续服用5型磷酸二脂酶抑制剂(PDE5i)治疗的临床效果与副反应。方法 51例糖尿病性勃起功能障碍(ED)患者口服PDE5i(他达拉非)5 mg每日1次,共12周。疗效指标包括"国际勃起功能指数"(IIEF-5)、性活动日志(SEP)、全球评估问卷(GAQ)。结果 51例患者勃起功能改善者42例,有效率为82.3%;治疗后IIEF-5评分有显著性提高(P<0.05);治疗后阴茎插入的成功率和保持勃起至完成性交的成功率明显增高(P<0.05)。GAQ1在治疗后肯定回答率为86.7%;GAQ2在治疗后肯定回答率为80.2%;治疗期间无严重不良反应发生。结论每日1次小剂量PDE5i持续服用可以有效治疗糖尿病ED患者,而且耐受性良好,无明显不良反应,同时可以替代按需服用。

Clinical efficacy of long-term small-dose PDE5 i in the treatment of diabetes erectile dysfunction

Objective To examine the effect of long-term small-dose PDE5 i in the treatment of diabetes erectile dysfunction.Methods Fifty-one diabetes ED patients received once-daily treatment with tadalafil at 5 mg for 1 2 weeks.Outcomes included ＂International Index of Erectile Function＂（IIEF-5 ）,Sexual Encounter Profile （SEP）,the Global Assessment Questionnaire （GAQ）.Results After 1 2 weeks of treatment,42 cases improved in 51 cases,with an effective rate of 82.3%.The IIEF-5 scores were significantly increased in 42 cases（P〈0.05）;After the treatment,the achievement ratio of penile insertion inpatient＇s diary and the achievement ratio of keeping erectile tocomplete coitus was significantly higher（P〈0.05）.GAQ1 in the treatment of affirmative response rate was 86.7%;GAQ2 in the treatment of affirmative answer rate was 80.2%,no serious adverse reactions during treatment period.Conclusions Oral tadalafil at 5 mg once daily is efficacious with good tolerance in the treatment of ED,and it can be an alternative to on-demand medication for some men to eliminate the inconvenience of planned intercourse within a limited timeframe.