| 瑞舒伐他汀、普伐他汀对轻中度原发性高血压患者冠状动脉粥样硬化的影响 |
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| 引用本文： | 张秋兰,晋万强,赵静茜.瑞舒伐他汀、普伐他汀对轻中度原发性高血压患者冠状动脉粥样硬化的影响[J].高血压杂志,2010(4). |
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| 作者姓名： | 张秋兰 晋万强 赵静茜 |
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| 作者单位： | 潍坊医学院临床系;潍坊市人民医院高血压科; |
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| 摘 要： | 目的评价瑞舒伐他汀对轻中度原发性高血压(EH)患者冠状动脉粥样硬化的影响,观察常规剂量、不同的他汀药物对轻中度EH合并冠状动脉硬化的早期干预作用。方法将68例(男40例,女28例)经双源螺旋CT血管造影(DSCTA)检查诊断并经过冠状动脉造影确诊的冠状动脉粥样斑块患者,随机分为瑞舒伐他汀(10 mg/d,n=34)组和普伐他汀(20 mg/d,n=34)组,1月复查总胆固醇、低密度脂蛋白胆固醇(LDL-C)不达标者剂量加倍,12月后复查DSCTA观察斑块变化。结果治疗12月后两组LDL-C、总胆固醇均较治疗前降低且瑞舒伐他汀组下降更显著(P<0.05)。治疗前后斑块引起的冠脉狭窄下降幅度为软斑块>纤维斑块>混合斑块>钙化斑块,且瑞舒伐他汀组下降更明显(P<0.05)。结论瑞舒伐他汀可有效降低胆固醇,能明显逆转冠脉粥样斑块,降低冠脉狭窄程度。
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| 关 键 词： | 冠状动脉粥样硬化 瑞舒伐他汀 冠状动脉CT血管造影 |
The Effect of Rosuvastatin and Pravastatin on Coronary Artery Plaque in Essential Hypertension |
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| ZHANG Qiu-lan,JIN Wang-qiang,ZHAO Jing-qian..Weifang Clinical Medical College .Weifang People\'s Hospital,Sh,ong province ,China.The Effect of Rosuvastatin and Pravastatin on Coronary Artery Plaque in Essential Hypertension[J].Chinese Journal of Hypertension,2010(4). |
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| Authors: | ZHANG Qiu-lan JIN Wang-qiang ZHAO Jing-qianWeifang Clinical Medical College Weifang People\'s Hospital Sh ong province China |
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| Institution: | ZHANG Qiu-lan1,JIN Wang-qiang2,ZHAO Jing-qian1.1.Weifang Clinical Medical College 2.Weifang People\'s Hospital,Sh,ong province 261041,China |
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| Abstract: | Objective To evaluate the effect of rosuvastatin on coronary artery plaque.Methods Sixty-eight patients with coronary artery atheromatous plaque were examined with dual source spiral CT and randomly divided into two groups:the treatment group receiving rosuvastatin 10 mg/d and the control group given pravastatin 20 mg/d for a continuous period of 12 months respectively.The changes of plaque and blood lipid were observed before and after the treatment.Results The TC and LDL-C of the treatment group were more... |
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| Keywords: | Coronary atherosclerosis Rosuvastatin CT coronary artery imaging |
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