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Recurrence of Thymoma with Appearance of Myasthenia Gravis 18 Years after Surgery: A Case Report |
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| Authors: | SHINKAI, TETSU SAIJO, NAGAHIRO YOSHIOKA, SENYA SUEMASU, KEIICHI HASEGAWA, HIROSHI MIYAZAWA, NAOTO KAMIYA, TOMOYOSHI KANZAWA, FUMIHIKO NAKAJIMA, TAKASHI SHIMOSATO, YUKIO |
| Affiliation: | 1Department of Internal Medicine, National Cancer Center Hospital Tokyo 2Department of Surgery, National Cancer Center Hospital Tokyo 3Nippon Kokan Hospital Kawasaki 4Pharmacology Division, National Cancer Center Research Institute Tokyo 5Pathology Division, National Cancer Center Research Institute Tokyo |
| Abstract: | A 59-year-old woman was admitted to the hospital because ofrecurrence of thymoma with appearance of myasthenia gravis 18years after excision of an invasive thymoma. Recurrence wasobserved in the anterior mediastinum, right pleura, pericardiumand left supraclavicular lymph node. Hashimoto's thyroiditis,vitiligo vulgaris and leukopenia were also seen. After creationof a pericardial window for pericardial effusion, she receivedvincristine, then carbazilquinone intravenously as single chemotherapeuticagents based on the chemosensitivity by clonogenic assay ofthe supraclavicular tumor, but response was not achieved. Atone and a half years after radiotherapy to the mediastinum,she is now doing well without symptoms and is receiving a fairlylow dose of anticholinesterase medication. |
| Keywords: | Thymoma Myasthenia gravis Chemotherapy |
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