室内氡暴露居民外周血淋巴细胞DNA损伤及微核细胞发生率

目的：观察室内氡暴露居民外周血淋巴细胞DNA损伤及微核细胞发生率。方法：采用单核细胞凝胶电泳和微核检测两种方法。观察了我国甘肃省窑洞内氡暴露居民及对照居民外周血淋巴细胞DNA损伤及微核细胞发生率。结果：窑洞和普通住房居民（室内空气中氡浓度分别为200－350Bq.m^－3及37．5-77.1Bq.m^－3)的细胞迁移发生率分别为1．68％和1．43％，人发生细胞迁移百分别为57．1％和54．3％。50岁以上窑洞和普通住房居民细胞迁移和人发生细胞迁移率分别为2．14％、75．0％和2．00％、64．7％。窑洞和普通住房居民微核细胞发生率分别为1．07％和0．78％。结论：窑洞居民外周血淋巴细胞DNA损伤及微核细胞发生率略高于普通住房居民，P值接近0．05。

DNA damage in peripheral blood lymphocytes of residents with radon exposure in indoor

Objective To determine the damage of DNA in peripheral blood lymphocytes samples from resident exposure to radon in indoor air. Methods Single cell gel electrophoresis and micronucleus measure methods were used in the present study. Results The results of cell migration frequencies for residents in cave dwellings and normal houses were shown 1.68% and 1.43%,of calculation by residents were 57. 1% and 54 3% respectively.The frequencies of micronucleus results for residents of cave dwellings and normal houses were 1. 07% and 0.78% respectively. Conclusion The frequencies of DNA damage and the ratio of micronucleus for residents living in cave dwellings was shown some higher than that of residents living in normal houses, p values close to 0. 05.