Multiple Overlapping Epitopes in the Repetitive Unit of the Shed Acute-Phase Antigen from Trypanosoma cruzi Enhance Its Immunogenic Properties |
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| Authors: | Paula Alvarez, M. Susana Leguizam n, Carlos A. Buscaglia, Tamara A. Pitcovsky, Oscar Campetella |
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| Affiliation: | Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martin, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. |
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| Abstract: | The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternative device to repetitiveness in order to improve its immunogenicity. |
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