| 溴氰菊酯对大鼠脑血红素氧化酶-1的影响 |
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| 引用本文： | 刘玉梅,吴玲,王基鸿,易聪.溴氰菊酯对大鼠脑血红素氧化酶-1的影响[J].中国医药导报,2008,5(9):24-25. |
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| 作者姓名： | 刘玉梅 吴玲 王基鸿 易聪 |
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| 作者单位： | 海南医学院预防医学系,海南海口,571101 |
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| 基金项目： | 海南医学院苗圃基金(2004109) |
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| 摘 要： | 目的：研究溴氰菊酯（DM）对大鼠脑皮质及海马血红素氧化酶-1（HO-1）mRNA及蛋白表达的影响。方法：健康SD雄性大鼠36只,随机分为对照组（腹腔注射色拉油）、低剂量DM组（腹腔注射1.25mg/kg DM）、高剂量DM组（腹腔注射12.5mg/kg DM）,连续染毒5d,末次染毒24h后以原位杂交法测定皮质及海马HO-1 mRNA的表达,以免疫组化法测定HO-1蛋白表达。结果：与正常对照组相比,高剂量DM组HO-1 mRNA表达阳性细胞数明显增多（P〈0.05）;而HO-1蛋白表达阳性细胞数则在低剂量DM组、高剂量DM组大鼠均明显增高（P〈0.05）,并随着染毒剂量的增加表达明显增强（P〈0.05）。结论：溴氰菊酯可诱导大鼠脑皮质及海马HO-1表达增加,发挥一定保护作用。
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| 关 键 词： | 溴氰菊酯 血红素氧化酶-1 大鼠 |
| 文章编号： | 1673-7210(2008)03(c)-024-02 |
| 修稿时间： | 2007年11月19 |
The effects of deltamethrin on heme oxygenase-1 in rats |
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| LIU Yu-mei,WU Ling,WANG Ji-hong,YI Cong.The effects of deltamethrin on heme oxygenase-1 in rats[J].China Medical Herald,2008,5(9):24-25. |
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| Authors: | LIU Yu-mei WU Ling WANG Ji-hong YI Cong |
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| Institution: | (Department of Preventive Medicine, Hainan Medical College, Haikou 571101,China) |
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| Abstract: | Objective:To observe the expression changes of heme oxygenase-1(HO-1) and its mRNA induced by delmathrin(DM) in rats.Methods:36 healthy male SD rats were randomly divided into control,low DM(1.25 mg/kg DM),high DM(12.5 mg/kg DM)exposed groups,by giving intraperitoneal injection for 5 days.The number of protein expression of hemeoxygenase-1 and its mRNA were detected at 24 hours after the last intraperitoneal administration.Results:The HO-1 and its mRNA expressed positive cells were significantly increased in high DM group(P<0.05).Conclusion:Deltamethrin could induce increase expression of HO-1. |
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| Keywords: | Deltamethrin HO-1 Rat |
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