影响儿童横纹肌肉瘤预后的危险因素

 目的　分析影响儿童横纹肌肉瘤（RMS）预后的危险因素。方法　对56例RMS病例资料进行回顾性分析。结果　单因素分析显示，肿瘤原发部位、大小、病理类型、临床分期、手术完全切除与否、不同治疗方案与RMS患儿生存时间存在相关性（P＜0.05）；多因素分析显示，临床分期是影响RMS患儿预后的独立危险因素（Wald值为8.762，P＝0.003）。结论　RMS的预后与肿瘤原发部位、肿瘤大小、病理类型、临床分期、手术完全切除与否相关，临床分期是影响RMS患儿预后的独立危险因素，将手术、放疗及化疗结合的综合治疗可提高RMS患儿生存率。

Risk factors on prognosis of children with rhabdomyosarcoma

Objective To investigate risk factors which affect the prognosis of children with rhabdomyosarcoma (RMS). Methods A total of 56 cases of RMS were evaluated in a retrospective analysis.Results In univariate analysis, tumor' s primary location and size, pathologic type, clinical stage,operation effect and therapeutic strategy were associated with prognosis of children with RMS (P <0.05). In multivariate analysis, clinical stage was an independent prognostic factor of RMS (x 2 = 8.762, P=0.003).Conclusion Tumor ' s primary location and size, pathologic type ,clinical stage, operation effect and therapeutic strategy are associated with the survival of children with RMS. Clinical stage is an independent prognostic factor of RMS. The therapeutic strategy combined with operation, adjuvant chemotherapy and radiotherapy can increase the survival rate.