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| 南京地区敏感褐家鼠凝血酶原时间的研究 | |
| 引用本文： | 周明浩,张爱军,孙俊,吴健,孙毅,刘大鹏,陈志龙,章进宝,楼文军. 南京地区敏感褐家鼠凝血酶原时间的研究[J]. 中国媒介生物学及控制杂志, 2004, 15(6): 427-429 |
| 作者姓名： | 周明浩 张爱军 孙俊 吴健 孙毅 刘大鹏 陈志龙 章进宝 楼文军 |
| 作者单位： | 1. 江苏省疾病预防控制中心消毒与媒介生物防制科,南京,210009 2. 军事医学科学院微生物流行病研究所 3. 江苏省卫生监督所 4. 南京市爱国卫生运动委员会办公室 |
| 基金项目： | 国家自然科学基金资助项目 (编号 :30 2 70 882 ) |
| 摘 要： | 目的 测定南京地区杀鼠灵对敏感褐家鼠的凝血酶原时间 (PT)。方法 PT测定采用仪器法 ,抗药性调查采用摄食试验。结果 南京地区 2 1只褐家鼠在观察期内全部死亡 ,平均致死剂量为 12 .4mg/kg,PT值 (以INR表示 )平均为 1.0 0 ,雌雄鼠差异无显著性 (P >0 .0 5 ) ,南京地区杀鼠灵对敏感褐家鼠PT值 (以INR表示 )为 0 .73～ 1.2 7。结论制定杀鼠灵对敏感或抗性褐家鼠的PT值 ,可大大简化鼠类抗药性调查工作。 |
| 关 键 词： | 杀鼠灵 褐家鼠 凝血酶原时间 |
| 修稿时间： | 2004-07-28 |
Study on Prothrombin Time of Susceptible Rattus norvegicus in Nanjing Region |
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| ZHOU Ming hao,ZHANG Ai jun,SUN Jun,et al.. Study on Prothrombin Time of Susceptible Rattus norvegicus in Nanjing Region[J]. Chinese Journal of Vector Biology and Control, 2004, 15(6): 427-429 | |
| Authors: | ZHOU Ming hao ZHANG Ai jun SUN Jun et al. |
| Affiliation: | ZHOU Ming hao,ZHANG Ai jun,SUN Jun,et al. Jiangsu Provincial Center of Disease Control and Prevention,Nanjing 210009,China |
| Abstract: | Objective To determine the prothrombin time (PT) of warfarin susceptible Rattus norvegicus in Nanjing region. Methods PT was determined by ST art 4 analyser and the dieting test was used in the study of resistance. Results All of Rattus norvegicus died during the observing period. The mean lethal dose was 12.4 mg/kg and the mean PT value (expressing by INR) was 1.00 . There was no significant difference between male and female rats( Pa0.05a). PT values of warfarin susceptible Rattus norvegicus in Nanjing region was 0.73 1.27 . Conclusion It would simplify the process in the study of resistance of rats to formulate the PT value of warfarin susceptible or resistant Rattus norvegicus . |
| Keywords: | Warfarin Rattus norvegicus Prothrombin time |
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