血浆B型利钠肽水平对心力衰竭患者的临床评价

目的 采用超声心动图评价心力衰竭患者的心功能指标,探讨其与血浆B型利钠肽（BNP）的相关性,观察应用心脉隆注射液对心力衰竭患者血浆BNP的影响.方法 入选2010年10月至2013年3月我院心内科临床诊断为心力衰竭的住院患者96例,随机分为两组：观察组49例（常规应用传统抗心力衰竭药物基础上加用心脉隆注射液）和对照组47例（常规应用传统抗心力衰竭药物）,2周后比较两组治疗前后血浆BNP水平及左室射血分数（LVEF）、左室舒张末内径（LVDd）大小,评价BNP与左心室功能的相关性.结果 两组治疗2周后LVEF均较前提高,LVDd及血浆BNP均较前下降,观察组有效率为91.84％,对照组有效率为78.72％,两组疗效差异有统计学意义（P＜0.05）.心力衰竭患者血浆BNP水平与LVDd大小呈正相关（r=0.536,P＜0.05）,与LVEF呈明显负相关（r=-0.619,P＜0.05）.结论 血浆BNP水平是评价心力衰竭的良好指标,可作为心力衰竭治疗后疗效评估的一个重要指标.在传统治疗心力衰竭的基础上联合应用心脉隆注射液能显著改善心功能,降低心力衰竭患者的血浆BNP水平,值得临床推广应用.

Clinical evaluation of plasma b-type natriuretic peptide levels in patients with heart failure

Objective To evaluate the relationship of Plasma b-type natriuretie peptide （BNP） with cardiac functional parameter by echocardiography has detected in heart failure patients, and to observe the effect of Xinmallong injection on the BNP in these patients. Methods During October 2010 to March 2013, 96 cases of heart failure patients were divided into observation group and control group in Cardiology of Baoding First Central Hospital. BNP levels and left ventricular ejection fraction （LVEF） and left ventrieular end-diastolic diameter （LVDd） size in observation group and control group were compared two weeks before and after treatment, and the relevance of BNP and LVEF were analyzed. Results After two weeks of treat- ment LVEF and LVDd and plasma BNP improved in two groups than before. Among them,the effective rate of observation group was 91.84%, the effective rate of control group was 78.72%. Eventually statistical analy- sis test showed statistically difference between observation group and control group（P〈0.05）. The plasma BNP level in heart failure patients had a positive correlation with LVDd （r=0.536,P〈0.05）. While also it had a significant negative correlation with LVEF （r=-0.619,P〈0.05）. Conclusion Plasma BNP level is a good in- dex for the evaluation of heart failure, it may be an important indicator to evaluate the prognosis. And while in the traditional treatment of heart failure based on combined application Xinmailong injection can signifi-candy improve heart function and reduce plasma BNP levels, worthy of clinical application.