迎春花水提取物镇静催眠作用的研究

目的：研究迎春花水提取物镇静催眠的影响。方法：取昆明种小鼠30只，随机分为生理盐水组、0.1g/kg、0.2g/kg迎春花水提取物组。采用抖笼法测定小鼠自发活动和对阈上、阈下剂量戊巴比妥钠小鼠睡眠时间的影响。结果：0.1g/kg、0.2g/kg的迎春花水提取物对小鼠自发活动具有明显抑制作用（P〈0.05；P〈0.01）。0.1g/kg、0.2g/kg的迎春花水提取物能显著（P〈0.05；P〈0.01）加速戊巴比妥钠的入睡时间和显著（P〈0.05；P〈0.01）延长戊巴比妥钠的睡眠时间，并与戊巴比妥钠有协同作用。结论：迎春花水提取物具有明显的抑制小鼠自发活动和镇静催眠作用。

Study on the sedative and hypnotic effect of jasminum nudiflorum lindl. aqueous extract

Objective To study the sedative and hypnotic effect of aqueous extract of Jasminum nudiflorum Lindl. Methods Thirty Kunming rats were divided into three groups including saline control group,0.1g/kg and 0.2g/kg of Jasminum nudiflorum Lindl. aqueous extract groups. Cage-shaking method was employed to observe the rats’locomotor activity,and how the pentobarbi-tal sodium at doses below and over the threshold affects the rat sleeping time. Results The rats’locomotor activity was significant-ly inhibited by administrating 0.1g/kg and 0.2g/kg of Jasminum nudiflorum Lindl. aqueous extract, the time to fall asleep was shorten and the sleeping time was prolonged after administrated pentobarbital sodium （P〈0.05;P〈0.01）,which proved to have syn-ergistic effect with pentobarbital sodium. Conclusion The aqueous extract of Jasminum nudiflorum Lindl. inhibit the rats’locomo-tor activity significantly thus show obvious hypnotic effect.